NEURAL CORRELATES OF COCAINE ADDICTION TREATMENT

描述：（申请人摘要） 戒毒康复可以分为三个主要阶段， 治疗，每一个特定的目标，解毒和戒断 缓解、减少药物使用和预防复发。 贯穿每个 在康复阶段，必须解决毒瘾的影响， 以有效的方式管理。 这也许是最关键的， 复发预防阶段的治疗，这在许多方面是最好的 衡量治疗结果的成功。 该提案将调查 治疗结果与条件性渴求反应之间的关系 可卡因依赖患者 它会利用线索诱导的可卡因渴望 旨在评估可卡因的心理和神经基础的研究 渴望和相关的线索诱导的状态，如唤醒，焦虑和 可卡因般的快感 这项研究的主要目的是测试是否 可卡因成瘾康复的积极结果与 具体减少线索诱导的可卡因渴望。 可卡因的慢性效应的神经生物学相关性已经被 通过基于神经成像和定量EEG（qEEG）的 问题研究 此外，心理生理学研究，如线索诱导 可卡因渴望提供了与可卡因成瘾相关的功能测量。 通过将qEEG测量与线索诱导的可卡因渴望研究相结合， 该提案将开发方法来检查神经生物学基础， 对可卡因的渴望 这项建议的次要目的是 探索线索诱发的qEEG、心理生理和 主观反应、成瘾严重程度和治疗结果。

DESCRIPTION: (Applicant's Abstract) Drug addiction rehabilitation can be described in three main phases of treatment, each with specific objectives, detoxification and withdrawal alleviation, reduction in drug use, and relapse prevention. Throughout each stage of rehabilitation the impact of drug craving must be addressed and managed in an effective manner. This is perhaps most critical during the relapse prevention phase of treatment, which in many regards is the best measure of treatment outcome success. This proposal will investigate the relationship between treatment outcome and conditioned craving responses in cocaine-dependent patients. It will employ cue-induced cocaine craving studies aimed at evaluating the psychological and neuronal basis of cocaine craving and related cue-induced states, such as arousal, anxiety and cocaine-like high. The primary aim of this study is to test whether positive outcomes in cocaine addiction rehabilitation are correlated with specific reductions in cue-induced cocaine craving. The neurobiological correlates of the chronic effects of cocaine have been well characterized by neuroimaging and quantitative EEG (qEEG) based studies. In addition, psychophysiological studies such as cue-induced cocaine craving provide a functional measure related to cocaine addiction. By combining qEEG measures with cue-induced cocaine craving studies this proposal will develop methods to examine the neurobiological basis of craving in cocaine addiction. The secondary aims of this proposal are to explore the relationships between cue-induced qEEG, psychophysiological and subjective responses, addiction severity and therapeutic outcome.