LIFE AND DEATH OF ANTIGEN ACTIVATED T CELLS IN VIVO

T细胞对入侵生物的反应能力，但不能 攻击自己的宿主对宿主的健康至关重要。 已知许多潜在的自身反应性T细胞死于 胸腺，在它们成为成熟的功能细胞之前。一些人 然而，自身反应性T细胞逃脱了胸腺。这些单元格必须 销毁的或停用的。 此前已有研究表明，许多成熟的T细胞在 遇到抗原。尽管已经提出了一些假设 为了解释为什么抗原会导致动物T细胞死亡，没有 实验还没有完全解释这一现象。在……里面 本项目将比较的各种机制包括Fas和 RNF受体诱导的死亡，由细胞毒性T细胞引起的死亡 因在不适当的抗原呈递上遇到抗原而引起的 B细胞等细胞和因停用生长因子而死亡。 与抗原相遇并不总是杀死抗原特异性T细胞 细胞。有时抗原特异性细胞存活下来，产生 高效的免疫反应。已有研究表明，共同暴露于 细菌脂多糖和抗原等炎性刺激 促进抗原特异性T细胞的分裂和存活。这 该项目将研究由炎症诱导的细胞因子是什么 对解救抗原刺激的T细胞至关重要。研究还将 试图找出哪些细胞因子必须直接作用于 被拯救的T细胞本身。

The ability of T cells to respond to invading organisms but not to attack their own host is crucially important to the health of the host. It is known that many potentially autoreactive T cells die in the thymus, before they become mature functional cells. Some autoreactive T cells escape the thymus however. These cells must be destroyed or inactivated. It has previously been shown that many mature T cells die when they encounter antigen. Although some hypotheses have been put forward to explain why antigen causes T cell death in animals, no experiments have yet accounted for the phenomenon completely. In this project the various mechanisms to be compared include Fas and RNF receptor-driven death, death caused by cytotoxic T cells, death caused by encounter with antigen on inappropriate antigen presenting cells such as B cells and death due to withdrawal of growth factors. Encounter with antigen does not always kill the antigen specific T cells. Sometimes antigen specific cells survive to give rise to productive immune responses. It has been shown that co-exposure to inflammatory stimuli such as bacterial lipopolysaccharide and antigen promotes the division and survival of antigen specific T cells. This project will investigate what cytokines induced by inflammation are critical to the rescue of antigen stimulated T cells. Studies will also be done to try to find out what cytokines must act directly on the rescued T cells themselves.