CORE--HUMAN TISSUE RESOURCE AND LOGISTICS

这个孢子中的所有程序都使用人类标本进行翻译研究 旨在降低结直肠癌的发病率和死亡率 胰腺癌。构建人体组织资源与物流核心 在1986年为肠道建立的非常成功的现有银行 肿瘤工作组。在1995年底，资源包括910 结直肠癌切除169例结直肠腺瘤切除52例 62例转移性大肠息肉切除标本 结直肠癌，胰腺癌切除，112例异种移植 结直肠癌97例胰腺癌异种移植瘤127例粪便 标本和2574份血液标本。收集资金的机制 孢子研究活动所需的标本仍留在原地 在不同的病人接触地点。这一核心设施的银行范围很广 大肠和胰腺切除标本的组织范围 癌症。该资源用于购买粪便和血液。 标本，包括外周血白细胞、血浆和血清 作为ERCP液、鼻胃和十二指肠囊液，以及腹膜 洗衣服。核心支持结直肠和胰腺异种移植 裸鼠体内的癌症。此外，分发和检索一个 饮食史和家庭标准化食物频率调查问卷 病史是通过核心进行的，患者的标本在 资源。核心包括一种数据库管理机制和 样本分发，包括确定请求的优先顺序的程序 约翰霍普金斯大学胃肠道癌症孢子内外的材料。 现有程序为研究提供了样本的质量控制。 不会影响诊断、临床重要的病理检查 通过病理学家的参与对标本进行评估 在结直肠癌和胰腺癌方面的专业知识。临床部成员 与患者有主要接触的科室是个人 研究项目，因此也有助于核心的最大和 有效地积累了令人满意的样本。

All programs in this SPORE use human specimens for translational research directed at reducing the incidence of and mortality from colorectal and pancreatic cancer. The Human Tissue Resource and Logistics Core was built upon the highly successful existing bank established in 1986 for the Bowel Tumor Working Group. At the end of 1995, the Resource included 910 colorectal cancer resections, 169 colorectal adenoma resections, 52 colorectal polypectomy specimens, 62 hepatic resections for metastatic colorectal cancer, 20l pancreatic cancer resections, 112 xenografts of colorectal carcinoma, 97 xenografts o pancreatic carcinoma, 127 fecal specimens, and 2574 blood specimens. The mechanisms for collecting specimens required for the research activities of the SPORE remain in place in the various patient contact locations. This Core facility banks a wide range of tissues from resection specimens for colorectal and pancreatic cancers. The Resource provides for procurement of fecal and blood specimens, including peripheral blood leukocytes, plasma and serum, as well as ERCP fluids, nasogastric and duodenal capsule fluid, and peritoneal washings. The Core supports xenografts of colorectal and pancreatic cancers in nude mice. In addition, the distribution and retrieval of a standardized food frequency questionnaire for dietary history and family history is carried out through the Core for patients with specimens in the Resource. The Core includes a mechanism for database management and specimen distribution, including procedures for prioritization of requested materials within and external to the Johns Hopkins GI Cancer SPORE. The existing procedures provide quality control of specimens for research without compromise of the diagnostic, clinically important pathological evaluation of the specimens via the participation of pathologists with expertise in colorectal and pancreatic cancer. Members of the clinical departments with primary patient contact are participants in the individual research projects and thus also contribute to the Core for maximal and effective accumulation of satisfactory specimens.