BECKMAN SYNCHRON CX5 DELTA CHEMISTRY ANALYSIS SYSTEM

新的基因技术与具有良好特性的基因组相结合，使小鼠成为人类疾病的首选哺乳动物模型。研究人员必须能够从基因和生理上描述它们的特征，以充分发挥它们的生物医学潜力。为了实现这一潜力，研究人员必须测量与人类诊断医学相同的基本临床化学参数。杰克逊实验室(TJL)的工作人员在定义标准近亲交配小鼠的标准生物学和表征数百种具有生物医学意义的新突变方面走在了前列。对于TJL工作人员开发的许多新的近交系和同源系，以及许多新的自发和诱导突变的表型特征，临床实验室测定是必不可少的。TJL目前还没有这样的仪器。自动化临床化学分析仪Synchron CX5 Delta，Beckman Instruments，Brea，CA，已在人类诊断医学中证明了其可靠性。由于它只需要少量的血清、血浆或尿液，因此该分析仪可以满足TJL工作人员对这些生物液中各种常见生化分析物的测量需求。CX5 Delta代表了一种测量这些相关生理参数的经济高效的机制。在TJL，超过86%的研究项目集中在遗传疾病的分析上。这些疾病包括由单基因突变引起的综合征或更复杂、多因素的遗传性疾病，如癌症、糖尿病和动脉粥样硬化。这样的研究产生了数以百计的后代，在这些后代中观察到了复杂性状的连续变异。准确测量相关生化亚型在这些群体中的分离是至关重要的。与自动收集各种生化参数相关的研究进展将极大地促进目前的项目。申请资金购买Beckman Synchron CX5系统，该系统将由该机构的微量化学处以服务费的方式运营，从而提供一种具有成本效益的方式来满足TJL工作人员目前未得到满足的紧急需求。

New genetic technologies combined with a well characterize genome make the mouse the preferred mammalian model for human disease. Investigators must be able to characterize them genetically and physiologically to exploit their full biomedical potential. To realize this potential, investigators must measure the same basic clinical chemistry parameters used in human diagnostic medicine. The staff of The Jackson Laboratory (TJL) is at the forefront both in defining the normative biology of standard inbred mice and in characterizing hundreds of new mutations of biomedical significance. Clinical laboratory determinations are essential for phenotypical characterization of the many new inbred strains and congenic lines developed by TJL Staff, and many new spontaneous and induced mutations. No such instrumentation currently exists at TJL. An automated clinical chemistry analyzer, the Synchron Cx5 Delta, Beckman Instruments, Brea, CA, has proven its reliability in human diagnostic medicine. Because it requires only small volumes of serum, plasma, or urine, this analyzer would meet the needs of TJL staff for measurement of a variety of common biochemical analytes in these biological fluids. The Cx5 Delta represents a cost-efficient mechanism for measuring these relevant physiologic parameters. At TJL more than 86% of research projects focus on the analysis of genetic disease. These include either syndromes caused by single gene mutations or more complex, multifactorial genetic diseases, such as cancer, diabetes, and atherosclerosis. Such studies generate many hundreds of progeny in which continuous variation in a complex trait is observed. Accurate measurement of relevant biochemical sub-phenotypes segregating in these populations is essential. Research progress associated with automated collection of a variety of biochemical parameters would greatly enhance current projects. Funds are requested to purchase the Beckman Synchron Cx5 System, to be operated by the institution's Microchemistry Service on a fee for service basis thus providing a cost-effective way to fill an urgent, and currently unmet need of TJL staff.