UPGRADE OF A 500MHZ NMR SPECTROMETER

这是波士顿学院8个主要用户的联合提案 化学系从事化学和生物技术的各个方面， 涉及有机、有机金属和生物的生物化学研究 化合物.该请求是为了升级一架老化的瓦里安团结500型飞机 光谱仪（老式1991年）的国家的最先进的研究工具，由 增加了数字RF发生器、第三RF通道、脉冲场 梯度、波形发生器和氢纳米探针。此次升级将 解决我们的非常规NMR需求的绝大多数， 灵敏度和分辨率，并允许更高的样品处理。的 将光谱仪升级到UNITY INOVA 500系统将打开 利用梯度和成形脉冲的整个新实验库， 包括更通用（和有效）的溶剂抑制技术， 相干路径选择方法和定制的激发轮廓 实验nonoprobe的可用性将有助于加快对 通过允许直接分析珠粒的组合文库产品 泥浆由于组合化学已成为一个重要的组成部分， 几个私家侦探的研究，这是一个关键的补充。 升级后的NMR光谱仪将提高生产率， 学生和博士后研究员动手接触一个重要的， 不断发展的化学和生物学技术。

This is a joint proposal from eight major users of the Boston College Chemistry Department engaged in various facets of chemical and biochemical research involving organic, organometallic, and biological compounds. The request is for funds to upgrade an aging Varian Unity 500 spectrometer (vintage 1991) to a state-of-the-art research tool by the addition of digital RF generation, a third RF channel, pulse field gradients, waveform generators, and a H nanoprobe. This upgrade will address the vast majority of our non-routine NMR needs by increasing sensitivity and resolution and allowing a higher sample processing. The upgrade of the spectrometer to a UNITY INOVA 500 system will open an entire library of new experiments utilizing gradients and shaped-pulses, including more current (and effective) solvent suppression techniques, coherence pathway selection methods, and tailored excitation profile experiments. The availability of a nonoprobe will help speed analyses of combinatorial library products by allow direct analyses of bead slurries. Since combinatorial chemistry has become an important part of several of the P.I.'s research, this is a critical addition. The upgraded NMR spectrometer will increase productivity and give students and postdoctoral fellows hands-on exposure to a vital and constantly evolving technique in chemistry and biology.