BIOMEDICAL ANALYTICAL ULTRACENTRIFUGATION

在过去的几十年里，大分子分析超离心在生物医学研究人员的研究中发挥了关键作用。贝克曼仪器公司开发的新型XL型分析超离心机，以及随之而来的令人兴奋的新实验技术和分析程序的发展，引发了分析超离心在生物医学研究中应用的复兴。XL分析离心机结合了增强的实验控制和数据收集，与20世纪50年代的老式E型离心机相比，它们取代了易用性。由于这些原因，阿尔伯特·爱因斯坦医学院的教职员工希望获得一台XL-I分析超离心机，并准备有效地利用这台仪器作为共享资源。爱因斯坦拥有一个由结构生物学家、生物物理化学家和分子生物学家组成的强大社区，他们的研究项目将从使用xml - i可访问的大分子关联信息中受益匪浅。XL-I将由大分子分析实验室（LMA）管理，这是一个共享资源设施，在过去的十年里一直为爱因斯坦学院提供最先进的分析仪器。参与此应用程序的几位爱因斯坦教师都是经验丰富的E型运动员，具有设计和进行分析超离心实验的技术专长，并愿意教他们的同事和新一代科学家这门优雅的艺术。

Macromolecular analytical ultracentrifugation has played key roles in the studies of biomedical researchers over the past decades. The development by Beckman Instruments of the new XL analytical ultracentrifuges and the concomitant development of exciting new experimental techniques and analysis procedures has sparked a renaissance in the application of analytical ultracentrifugation to contemporary questions in biomedical research. The XL analytical centrifuges combine enhanced experimental control and data collection with ease of use compared to the 1950s vintage Model E centrifuges that they supplant. For these reasons, the faculty of the Albert Einstein College of Medicine desire to acquire an XL-I analytical ultracentrifuge and are poised to make effective use of this instrument as a shared resource. Einstein possesses a strong community of structural biologists, biophysical chemists and molecular biologists whose research programs will benefit enormously by the information on macromolecular association that is accessible using the XL-I. The XL-I will be administered by the Laboratory for Macromolecular Analysis (LMA), a shared resource facility that has been providing state of the art analytical instrumentation to the Einstein faculty for the past decade. Several Einstein faculty participating in this application are experienced Model E jocks with the technical expertise to design and conduct experiments in analytical ultracentrifugation and a willingness to teach their colleagues and a new generation of scientists this elegant art.