OTHER CANCERS IN FAMILIES OF WILMS TUMOR PATIENTS: NEOPLASM & SYNDROMES

克罗恩病和溃疡性结肠炎是主要形式 慢性炎症性肠病。这些疾病发生在 估计患病率超过千分之一的年轻人 西方国家的居民。去年，我们集团报告了一项 克罗恩病与前降粒染色体的显著连锁 16.这一发现后来被四个独立的 组。一个新的欧洲合作组织刚刚成立。 继续并扩大克罗恩病家系的收集工作 几个欧洲国家。这些新的家庭将帮助目前的 努力对16号染色体区域和 最终分离出这个基因。这一大群家庭 也将用于进一步努力定位与基因有关的基因 对克罗恩病的易感性。

Crohn's disease and ulcerative colitis constitute the major forms of chronic inflammatory bowel diseases. These disorders occur in young adults with an estimated prevalence of more than 1/1000 inhabitants in western countries. Last year, our group reported a significant linkage of Crohn's disease to pericontromeric chromosome 16. This finding has since been replicated by four independent groups. A new European collaborative group has just been established to continue and expand the collection of Crohn's disease families from several European countries. These new families will assist current efforts to perform fine mapping of the chromosome 16 region and ultimately to isolate this gene. This large collection of families will also be used in further efforts to locate genes conferring susceptibility to Crohn's disease.