DEVELOPMENT OF RAMAN SPECTROSCOPY FOR IN VIVO DIAGNOSIS BREAST CANCER

本项目的目标是开发一种基于拉曼的 用于乳房组织实时原位诊断的技术 针吸活检或手术。 我们以前已经表明，拉曼 光谱学可用于原位组织化学分析， 生物组织 该项目的第一部分涉及设计 光纤探针能够传递和收集 所需的光被研究的组织。 第二部分 取决于一种算法的发展， 组织的拉曼光谱。 我们已经确定， 疾病分类所需的资料载于 拉曼光谱。 现在我们需要确定哪些化学物质 负责这些差异的拉曼光谱，并制定了一个 决策算法 与此同时，我们正在设计一个合适的 用于获得体内拉曼光谱的探针。

The objective of this project is to develop a Raman based technique for real-time, in situ diagnosis of breast tissue during needle biopsy or surgery. We have previously shown that Raman spectroscopy can be used for in situ histochemical analysis of biological tissue. The first part of this project involves the design of a fiber-optic needle probe capable of delivering and collecting the necessary light to the tissue being studied. The second portion depends on the development of an algorithm for classifying breast tissue based on its Raman spectra. We have already established that the information necessary for disease classification is contained in the Raman spectra. Now we need to determine which chemicals are responsible for these differences in the Raman spectra and develop a decision algorithm. Simultaneously, we are designing an appropriate probe for obtaining in vivo Raman spectra.