A multi-cohort investigation of the effects of BDNF Val66Met on tau, neurodegeneration and cognition in preclinical Alzheimer’s disease

目前还没有针对阿尔茨海默病的治疗方法。我们将阐明基因多态性的作用，该基因多态性先前已被证明对与阿尔茨海默病相关的记忆衰退和脑容量减少具有神经保护作用。通过研究该基因在不同程度阿尔茨海默病风险个体的多个队列中的作用，本研究具有很高的潜力，可以发现治疗该疾病的新型疾病修饰策略。

There are currently no disease modifying therapies for Alzheimer’s disease. We will elucidate the role of a genetic polymorphism that has previously been shown to exert neuroprotective effects on memory decline and brain volume loss associated with Alzheimer’s disease. By studying the role of this gene in multiple cohorts of individuals with varying degrees of Alzheimer’s disease risk, this study has high potential to uncover novel disease-modifying strategies for the treatment of the disease.