EFFECTS OF INHALED NITRIC OXIDE(NO) ON OXIDANT INJURY IN INFANTS W/RESP. FAILURE

吸入一氧化氮(INO)是一种令人兴奋的新疗法，正在用于 新生儿患有严重的肺部疾病，已显示出巨大的成功 临床研究。一氧化氮(NO)是一种已知的分子。 仅作为汽车尾气和香烟中的一种环境污染物 烟。然而，已经发现NO可以扩张心脏血管。 肺使受损的肺能够更多地转移氧气和二氧化碳 有效地。在新生儿中使用它的长期影响是 不知道。 该项目建议调查INO疗法是否会导致证据 与长期接触的伤害相似 氧气。这种伤害的证据将通过以下方式寻找 婴幼儿服用NO和氧还原液的血液实验研究 只有氧气。这些结果也将与来自 正常的婴儿。样本取自重症监护室的婴儿。 帕卡德儿童医院的护理托儿所，研究是 在菲利斯·丹纳利的实验室处理过。 初步结果显示氧化损伤明显增加。 与之相比，服用NO的婴儿体内的抗氧化剂防御能力减弱 到接受高浓度氧气的婴儿。而不似乎是 是治疗严重呼吸衰竭的重要疗法，长期使用 可能与慢性肺等不良后果有关 疾病。 该项目有能力通过增加儿童的 关于INO疗法的毒性的知识。如果有重要意义 INO治疗发现异常，这一信息将被 对指导新生儿进一步使用这种疗法至关重要。

Inhaled nitric oxide (INO) is an exciting new therapy being used in newborns with severe lung disease which has shown great success in large clinical studies. Nitric oxide (NO) was a molecule previously known only as an environmental pollutant found in car exhaust and cigarette smoke. However, NO has been found to dilate the blood vessels in the lung enabling injured lungs to transfer oxygen and carbon dioxide more effectively. The long term effects of its use in newborn infants are not known. The project proposes to investigate whether INO therapy causes evidence of injury similar to that which is seen with prolonged exposure to oxygen. Evidence of this type of injury will be sought by doing laboratory studies on the blood of infants receiving NO and oxgyen and oxygen alone. These results will also be compared to samples from normal infants. The samples are drawn from infants in the Intensive Care Nursery at Packard Children's Hospital and the studies are processed in Phyllis Dennery's laboratory. Preliminary results demonstrate a definite increase in oxidative injury and depleted antioxidant defenses in infants receiving NO when compared to infants receiving high oxygen concentrations. While NO appears to be an important therapy for severe respiratory failure, prolonged use may be associated with adverse consequences such as chronic lung disease. This project has the ability to benefit children by increasing the knowledge about the toxicities of INO therapy. If signficant abnormalities are found with INO therapy, this information will be critical to guide further use of this therapy in newborns.