MECHANISMS OF CORTISOL SUPPRESSION IN SOCIALLY SUBORDINATE FEMALE MARMOSETS

目的探讨血管紧张素转换酶的调节机制，为临床治疗提供依据。 心理诱导性应激激素皮质醇的抑制 在社会上处于从属地位，繁殖能力受到抑制的雌性绒猴。 结果慢性应激激素抑制或升高 皮质醇经常与神经精神障碍有关 人类。作为这些内分泌紊乱的可能模型，我们有 一直在调查慢性皮质醇抑制的原因 在社会上处于从属地位，繁殖能力受到抑制的雌性绒猴。至 目前，我们检测了(1)基线促肾上腺皮质激素 (ACTH)水平，以确定皮质醇抑制是否由 减少垂体对肾上腺皮质的刺激；(2)ACTH和 皮质醇对合成糖皮质激素地塞米松的反应 确定下属女性是否表现出对 糖皮质激素负反馈；以及(3)皮质醇对 外源性ACTH，以确定皮质醇抑制是否 与肾上腺敏感度降低有关。目前为止的结果 表明无论是基线血浆ACTH水平还是垂体 不同组的肾上腺皮质对地塞米松的反应也不同。 然而，从属的雌性表现出迟钝的肾上腺皮质反应 外源ACTH。这些结果表明，肾上腺皮质激素减少 反应性是肾上腺皮质抑制的重要组成部分 在从属的雌性身上。未来的方向我们将继续 研究生理、生化和分子机制。 雌性绒猴的肾上腺皮质抑制作为一种 人类神经精神病学中的肾上腺皮质功能失调模型 精神错乱。关键词优势、从属、卵巢周期、肾上腺 皮质、促肾上腺皮质激素、糖皮质激素为NIMH提供资金 MH53709-01出版物Saltzman，W.，N.J.Schultz-Darken，F.H. Wegner，D.J.Wittwer和D.H.Abbott。1998年。皮质醇的抑制作用 雌性绒猴的生殖和社会水平 贡献。荷尔蒙与行为33：58-74。首页--期刊主要分类--期刊细介绍--期刊题录与文摘内容. 新泽西州舒尔茨-达肯·萨尔茨曼和P.L.坦南鲍姆1998年。 雌性绒猴对从属地位的适应。 比较生物化学与生理学第C119部分：261-274。[J]

OBJECTIVE To identify the mechanisms which mediate the psychosocially induced suppression of the stress hormone cortisol in socially subordinate, reproductively suppressed female marmosets. RESULTS Chronic suppression or elevation of the stress hormone cortisol is often associated with neuropsychiatric disorders in humans. As a possible model for these endocrine disturbances, we have been investigating the causes of chronic cortisol suppression in socially subordinate, reproductively suppressed female marmosets. To date, we have examined (1) baseline adrenocorticotrophic hormone (ACTH) levels, to determine whether cortisol suppression is caused by reduced pituitary stimulation of the adrenal cortex; (2) ACTH and cortisol responses to dexamethasone, a synthetic glucocorticoid, to determine whether subordinate females exhibit enhanced sensitivity to glucocorticoid negative feedback; and (3) cortisol responses to exogenous ACTH, to determine whether cortisol suppression is associated with reduced adrenal sensitivity. Results thus far indicate that neither baseline plasma ACTH levels nor the pituitary and adrenocortical responses to dexamethasone differ between groups. Howev er, subordinate females show a blunted adrenocortical response to exogenous ACTH. These results suggest that reduced adrenocortical responsiveness is an important component of adrenocortical suppression in subordinate females. FUTURE DIRECTIONS We will continue to investigate the physiological, biochemical, and molecular mechanisms of adrenocortical suppression in subordinate female marmosets as a model of adrenocortical dysregulation in human neuropsychiatric disorders. KEY WORDS dominance, subordination, ovarian cycle, adrenal cortex, adrenocorticotrophic hormone, glucocorticoids FUNDING NIMH MH53709-01 PUBLICATIONS Saltzman, W., N.J. Schultz-Darken, F.H. Wegner, D.J. Wittwer, and D.H. Abbott. 1998. Suppression of cortisol levels in subordinate female marmosets Reproductive and social contributions. Hormones and Behavior 33:58-74. [J] Abbott, D.H., W. Saltzman, N.J. Schultz-Darken, and P.L. Tannenbaum. 1998. Adaptations to subordinate status in female marmoset monkeys. Comparative Biochemistry and Physiology Part C 119:261-274. [J]