PATHOGENESIS OF SV40 INFECTIONS IN MACAQUES W/ AIDS

灵长类多瘤病毒包括JCV和BKV，它们感染 人和猕猴的密切相关的SV 40 宿主，原发性感染发生在生命早期， 临床症状病毒然后作为潜伏感染持续存在，主要在 肾脏再激活伴病毒脱落可发生于妊娠期， 慢性疾病或免疫功能低下，可能或可能不相关 临床症状JCV与进行性多灶性 白质脑病（PML），一种中枢神经系统脱髓鞘疾病， 神经系统（CNS）由于少突胶质细胞感染，高达5% 艾滋病患者BKV引起间质性肾炎和/或出血性肾炎 膀胱炎，特别是在移植受者中。 与SIV感染猕猴的PML和肾炎相关， 猴艾滋病以前的研究表明，SV 40引起间质性 原发性感染中的肾炎，以及潜在的 SIV感染猕猴的感染我们现在认识到第二个CNS SV 40 a脑膜脑炎累及大脑灰质的表现 与PML不同，这种病变可以是一种 SV 40的主要表现与SV 40诱导的 间质性肾炎SV 40的原位杂交 胶质细胞酸性蛋白免疫组化 部分，证明了许多感染的细胞中， 脑膜脑炎病变是星形胶质细胞，与PML相反， 大多数感染细胞是少突胶质细胞

The primate polyomaviruses include JCV and BKV, which infect humans, and the closely related SV40 of macaques In immunocompetent hosts, primary infection occurs early in life, with mild or absent clinical signs The virus then persists as a latent infection mainly in kidney Reactivation with viral shedding can occur with pregnancy, chronic diseases or immunocompromise, and may or may not be associated with clinical signs JCV is associated with progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the central nervous system (CNS) due to infection of oligodendrocytes, in up to 5% of AIDS patients BKV causes interstitial nephritis and/or hemorrhagic cystitis, particularly in transplant recipients Similarly, SV40 is associated with both PML and nephritis in SIV-infected macaques with simian AIDS Previous studies indicated that SV40 causes interstitial nephritis in primary infections, and PML upon reactivation of a latent infection in SIV-infected macaques We now recognize a second CNS manifestation of SV40 a meningoencephalitis affecting cerebral gray matter, without demyelination, distinct from PML This lesion can be a primary manifestation of SV40 in conjunction with SV40-induced interstitial nephritis In situ hybridization for SV40, coupled with immunohistochemistry for glial fibrillary acidic protein on the same section, demonstrates that many of the infected cells in the meningoencephalitic lesions are astrocytes, in contrast to PML, where the majority of infected cells are oligodendrocytes