SOMATOSENSORY SYSTEM ROLE IN MANUAL DEXTERITY & BILATERAL COORDINATION

为了确定躯体感觉神经元在神经系统中的作用， 系统到复杂的灵长类动物行为，如手工灵巧， 双边协调的手，多式联运一体化， 目标导向达成所需的感觉运动整合。 的 人类这些能力的进化与 我们的感觉和运动系统的进化。 因而为了 了解这些复杂的行为是如何在人类中产生的， 我们必须揭示我们的感官组织的细节， 系统，以及支持复杂功能的神经回路。 目的本研究旨在揭示 皮层野组织，感受野大小，刺激 偏好，以及详细的地形连接模式的领域， LS和PP在猴子中，并在确定是否存在类似的领域， 人类 结果最近，已经确定， 技术可以有效地用于确定地形 字段的组织以及区域内的细分数量 皮质 因此，与我们的电生理和 在猴子的连接研究中，我们将利用fMRI技术， 探索人类大脑皮层的类似区域。 我们的刺激 选择和感兴趣的领域将以我们的结果为指导， 猴子 因此，我们将开始与刺激一样， 上面，并直接我们的努力，在外侧沟的地区， 后顶叶皮层 应用皮层场的框架 以及在我们的猴子模型中建立的与人类的连接模式， 我们可以扩展我们的刺激系统， 任务涉及双边操纵，目标导向达成， 和注意力 这项研究是第一次努力， 联合收割机将不同类型的技术结合在人类和非人类身上 初步测试，并承诺提供一个更丰富的了解人类 躯体感觉皮层及其对高级知觉和 认知加工 今后的方向 我们的猴子大脑中建立的皮层区域和连接模式 我们可以扩展我们的刺激库， 复杂的任务，涉及双边操纵，目标 有针对性的接触和注意力。 这项研究代表了 首次尝试将联合收割机不同类型的技术结合在人体和 和非人类灵长类动物，并承诺提供更丰富的理解， 人的躯体感觉皮层，其贡献较高， 知觉和认知加工。 关键词躯体感觉区， 新皮层，认知加工McDonnell Fdn.格兰特 98-42 CNS-QUA.05

Significance To determine the contribution of the somatosensory system to complex primate behaviors such as manual dexterity, bilateral coordination of the hands, multimodal integration, and sensorimotor integration required for goal directed reaching. The evolution of these abilities in humans is firmly intertwined with the evolution of our sensory and motor systems. Thus, in order to understand how these sophisticated behaviors are generated in humans, we must uncover the details of the organization of our sensory systems, and the neural circuitry that subserves complex functions. Objectives The studies are aimed at uncovering the topographic organization of cortical fields, receptive field size, stimulus preference, and detailed topographic connection patterns of fields in LS and PP in monkeys, and at determining if similar fields exist in humans. Results Recently, it has been established that the fMRI technique can be used effectively to determine the topographic organization of fields, and the number of subdivisions within a region of cortex. Thus, in parallel with our electrophysiological and connection studies in monkeys, we will utilize fMRI techniques to explore similar regions of the neocortex in humans. Our stimulus selection and areas of interest will be guided by our results in monkeys. Thus, we will begin with stimulation like that described above, and direct our efforts to areas in the lateral sulcus and posterior parietal cortex. Applying the framework of cortical fields and patterns of connections established in our monkey model to humans, we can expand our stimulus repertoire to include more sophisticated tasks which involve bilateral manipulation, goal directed reaching, and attention. This study represents one of the first efforts to combine different types of techniques in both human and non-human prima tes, and promises to provide a richer understanding of human somatosensory cortex, and its contribution to higher perceptual and cognitive processing. Future Directions Applying the framework of cortical fields and patterns of connections established in our monkey model to humans, we can expand our stimulus repertoire to include more sophisticated tasks which involve bilateral manipulation, goal directed reaching, and attention. This study represents one of the first efforts to combine different types of techniques in both human and non-human primates, and promises to provide a richer understanding of human somatosensory cortex, and its contribution to higher perceptual and cognitive processing. KEY WORDS somatosensory area, neocortex, cognitive processing FUNDING James S. McDonnell Fdn., Grant 98-42 CNS-QUA.05