因生长激素缺乏而导致生长迟缓的儿童中的 HGH 表达-猫眼课题宝

因生长激素缺乏而导致生长迟缓的儿童中的 HGH 表达

批准号：

6116891

负责人：

THOMAS MOSHANG

金额：

$2.47万

依托单位：

CHILDREN'S HOSP OF PHILADELPHIA

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-12-01 至 1999-11-30

来源：

https://reporter.nih.gov/project-details/6116891

关键词：

child (0-11) clinical research drug screening /evaluation hormone therapy human subject human therapy evaluation hypoglycemia pharmacokinetics postnatal growth disorder slow release drug somatotropin

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中文摘要

翻译

本研究是一种长效新制剂的短期试验

英文摘要

This study is a short-term trial of a new formulation of a long acting growth hormone (hGH) to evaluate its safety and efficacy. The treatment of growth hormone deficiency (GHD) since the late 1960's initially with cadaveric hGH and then, subsequently, with recombinant hGH, has not changed in terms of method of administration of the hormone. The children were treated with frequent injections of hGH. Initially, this was three times per week intramuscularly and present standard treatment is daily subcutaeous injections of hGH. The present drug to be tested is a commercial growth hormone combined into a polyacrimide substance presently used as a dissolvable suture material to provide, theoretically, a slow release long acting hGH. This study is intended to evaluate possible side effects and short term efficacy. Future plans include a long term study of this drug to evaluate efficacy.

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