GCRC-GENOTYPE/PHENOTYPE CORE

位于洛杉矶县的综合临床研究中心（GCRC） 哈博加州大学洛杉矶分校医学中心（HUMC）现在是在其第二十七个年头， 操作本提案要求继续支持第28赠款年 至32（1996年12月1日至2001年11月30日），用于住院部（6张病床，1 200人 日）、门诊设施（4 000次就诊）、a围产期临床研究 HUMC中心（PCRC），Martin Luther King-Drew Medical的卫星PCRC 中心（KDMC）（13，000个护理小时）和Cedars Sinai的卫星GCRC 医疗中心（CSMC）（33，059 GCRC工作人员小时）。当前应用程序 包括101项协议：其中79项将利用住院/门诊患者 22个将使用HUMC和KDMC的PCRC，5个将同时使用 GCRC和PCR以及44个协议将在CSMC使用GCRC。我们 来自这三个地点的调查人员分别驻在 内科、儿科、妇产科、外科、精神科、 急诊医学、放射学和神经病学， 亚专科，包括过敏/免疫学、心脏病学、内分泌学 代谢、营养、遗传学、血液学/肿瘤学、传染病 疾病、血液学、胃肠病学、重症监护医学、肺 医学，眼科学，泌尿学，药理学，卫生服务，医学 放射学。我们GCRC的研究重点是男性生殖 内分泌学和避孕药的发展， 药物滥用性痴呆，睡眠的神经内分泌学， 种族，运动和生长，疾病的遗传基础（炎症 肠道疾病、糖尿病、动脉粥样硬化）和肝脏支持 系统.为了满足我们调查人员的需求， 医疗改革，我们建议：1）扩大我们的门诊 活动; 2）开发身体成分核心实验室; 3）增加 在KDMC的活动;以及4）建立卫生服务研究服务 在CSMC中心。这些战略发展将使我们能够提供核心 支持我们的调查人员的多方面需求，包括高 强度住院研究（例如，代谢、多重采样、睡眠）， 高容量门诊研究（例如，妇女健康倡议，糖尿病 西班牙裔的糖尿病），围产期研究（例如，念珠菌流行病学 母亲和新生儿感染）和“保健结果”研究 健康服务研究中心

The General Clinical Research Center (GCRC) at Los Angeles County Harbor-UCLA Medical Center (HUMC) is now in its twenty-seventh year of operation. This proposal requests continued support for grant year 28 through 32 (12/1/96 to 11/30/01) for an inpatient unit (6 beds, 1200 days), outpatient facilities (4,000 visits), a Perinatal Clinical Research Center (PCRC) at HUMC, a satellite PCRC at Martin Luther King-Drew Medical Center (KDMC) (13,000 nursing hours) and a satellite GCRC at Cedars Sinai Medical Center (CSMC) (33,059 GCRC staff hours). The current application includes 101 protocols: 79 of which will utilize inpatient/outpatient facilities at HUMC, 22 will use the PCRC at HUMC and KDMC, 5 will use both GCRC AND PCRCs, and forty-four protocols will use the GCRC at CSMC. Our investigators from the three sites are based in the Departments of Medicine, Pediatrics, Obstetrics/Gynecology, Surgery, Psychiatry, Emergency Medicine, Radiology and Neurology with a wide range of subspecialties, including Allergy/Immunology, Cardiology, Endocrinology and Metabolism, Nutrition, Genetics, Hematology/Oncology, Infectious Disease, Hematology, Gastroenterology, Critical Care Medicine, Pulmonary Medicine, Ophthalmology, Urology, Pharmacology, Health Services, Medicine and Radiology. Our GCRC's focus in research has been on male reproductive endocrinology and contraceptive development, neuroimaging of patients with dementia of drug abuse, neuroendocrinology of sleep, psychobiology of ethnicity, exercise and growth, genetic basis of diseases (inflammatory bowel disease, diabetes mellitus, atherosclerosis) and liver support systems. To meet the needs of our investigators and to ride the wave of health care reform, we are proposing: 1) to expand our outpatient activity; 2) develop a body composition core laboratory; 3) increase activity at KDMC; and 4) establish a health services research service center at CSMC. These strategic developments will allow us to provide core support for the multifaceted needs of our investigators including high intensity inpatient studies (e.g., metabolic, multiple sampling, sleep), high volume outpatient studies (e.g., Women's Health Initiative, Diabetes Mellitus in Hispanics), perinatal studies (e.g., epidemiology of candida infection in mothers and newborns), and "health care outcome" research with the proposed health services research center.