AGING, TRAINING, AND SKELETAL MUSCLE BLOOD FLOW DURING EXERCISE

这项研究的目的是更多地了解心血管系统中与年龄相关的变化是如何影响人类锻炼大小肌肉群的能力的。目前还不清楚，随着年龄的增长，人类运动能力的下降是由于最大肌肉血流量减少还是心输出量减少。在这项研究中，研究人员将确定是否有证据支持这两种可能性。我们在该方案的非侵入性方面取得了重大进展，并开展了研究，使我们能够确定老年人骨骼肌质量与运动耐受性之间的关系。我们还研究了心输出量、肌肉质量和老年人运动时摄氧量增加之间的关系。此外，我们已经启动了我们的侵入性研究，以更好地定义老年人运动时腿部血流的反应。该项目的数据已被用作试点研究，允许大卫·普罗克特博士向美国国立卫生研究院提交拨款提案。由于该协议的结果，用于研究运动反应和在老年受试者中使用运动方案的方法在梅奥得到了扩展。

The aim of this study is to learn more about how age-related changes in the cardiovascular system affect the ability of humans to exercise with large and small muscle groups. Currently it is unclear if the reduced exercise capacity seen in humans as they age is a result of reduced maximal muscle blood flow or a reduction in cardiac output. In this study, the investigators will determine whether there is evidence to support either possibility. We made strong progress in the non-invasive aspects of this protocol and conducted studies that allowed us to determine the relationship between skeletal muscle mass and exercise tolerance in aging humans. We have also looked at the relationship between cardiac output, muscle mass, and the rise in oxygen uptake that occurs with exercise in aging humans. Additionally, we have initiated our invasive studies to better define the leg blood flow responses to exercise in aging humans. Data from this project has been used as a pilot study that has permitted Dr. David Proctor to submit a grant proposal to the NIH. The approaches used to stud exercise responses and use of exercise protocols in aging subjects have been expanded at Mayo as a result of this protocol.