TESTOSTERONE DEFICIENCY & BONE LOSS

为了确定睾丸切除术是否与骨髓细胞产生白细胞介素-1（IL-1）、肿瘤坏死因子（TNF）、白细胞介素-6（IL-6）和前列腺素E2（PGE）的增加以及胫骨松质骨的丢失有关，以及白细胞介素-1受体拮抗剂（IL-1 ra）、TNF结合蛋白（TNFbp）、中和IL-6抗体（IL-6ab）或非甾体类抗炎药（NSAID）萘普生。 在大鼠中，确定睾丸切除术是否与长骨中转化生长因子B（TGFB）的丢失和胫骨松质骨的丢失相关，TGFB的丢失是否被T阻止，骨丢失是否被TGFB阻止。 为了确定在患有前列腺癌的男性中，由药物或手术睾丸切除术产生的T缺陷是否与IL-1a、IL-1B、IL-6、TNF α、粒细胞-单核细胞集落刺激因子（GM-CSF）的分泌增加相关，PGE 2或TGFB的骨髓细胞和IL-12的表达。如果NSAID双氯芬酸钠阻止骨吸收增加，并确定T缺乏和年龄对男性骨标志物、骨矿物质密度（BMD）和骨组织形态计量学的影响。

To determine if orchiectomy is associated with increased production of interleukin -1 (IL-1), tumor necrosis factor (TNF), interleukin-6 (IL-6) and prostaglandin e2 (PGE@) by bone marrow cells and loss of canellous bone of the tibia and if bone loss is prevented by interluekin-1 receptor antagonist (IL-1ra), TNF binding protein (TNFbp), a neutralizing IL-6 antibody (IL-6ab) or the nonsteroidal antiinflammatory drug (NSAID) naproxen, respectively. To determine in rats if ochiectomy is associated with loss of transforming growth factor B (TGFB) in long bones and loss of canellous bone of the tibia, if loss of TGFB is prevented by T and if bone loss is prevented by TGFB. To determine in men with prostate cancer if T deficiency produced by medical or surgical orchiectomy is associated with increased secretion of IL-1a, IL-1B, IL-6, TNFa, granulocyte-monocyte colony-stimulating factor (GM-CSF), PGE2 or TGFB by bone marrow cells and of IL-1B by peripheral monocytes and increased bone resorption and if the NSAID diclofenac sodium prevents increased bone resorption and to determine the effects of T deficiency and age on bone markers, bone mineral denisty (BMD) and bone histomorphometry in men.