INTRAVENOUS LIDOCAINE IN TREATMENT OF NEUROPATHIC PAIN SYNDROMES

神经性疼痛综合征通常难以治疗。神经性疼痛发生在周围和中枢神经系统损伤之后。这些疼痛综合征的患者有不同类型的疼痛（持续性疼痛、阵发性疼痛、诱发性疼痛），其严重程度各不相同。神经性疼痛可伴有不同程度的相关感觉和运动缺陷。众所周知，这些疼痛综合征对标准疼痛治疗（包括阿片类镇痛药）反应较差。最近的报告表明，系统给予局部麻醉剂可以缓解这些综合征的疼痛。然而，尚不清楚镇痛反应是否与剂量和血清浓度有关。本课题拟研究静脉注射利多卡因镇痛效果与利多卡因血药浓度的关系。本研究将建立浓度-响应曲线。这项研究的结果将提供利多卡因治疗这些严重疼痛和治疗难治性疼痛综合征的最佳剂量信息。

Neuropathic pain syndromes are often difficult to treat. Neuropathic pain occurs following injury of the peripheral and central nervous system. Patients with these pain syndromes have various types of pains (constant pain, paroxysms of pain, evoked pain), which are variable in severity. Neuropathic pain may be accompanied by variable degrees of associated sensory and motor deficits. These pain syndromes are known for they poor responsiveness to standard pain treatments, including opiate analgesics. Recent reports suggest that systemically administered local anesthetics provide pain relief in these syndromes. However it is not established if the analgesic responses are dose and serum concentration related. This project proposes to study the relation of pain relief obtained with intravenous lidocaine and lidocaine serum concentration. In this study the concentration-response curve will be established. Results of this study will provide information how optimally to dose lidocaine for treatment of these severely painful and treatment resistant pain syndromes.