BIOMEDICAL IMPLICATIONS OF MAGNETIC SUSCEPTIBILITY

该计划项目赠款提案寻求继续支持， 研究旨在更全面地了解和 磁化率和其他固有特性的新应用 NMR对比机制，提供体内生理 信息. 本研究探讨了 微观生物区室化和宏观 NMR图像对比度。 尽管在这方面取得了很大进展， 了解这些现象，因为它们涉及到测量 血容量和铁生化，许多未解决的问题， 特别是关于灌注、耗氧量， 目标的有效性仍然存在。 协调调查 提供这些效果以提高MR成像的利用率 在各种器官系统和病理状态下，包括 癌症和冠状动脉疾病 真实的时间的可用性 回波平面成像作为研究这些问题的工具 继续提供新的机遇和科学挑战。 该项目分为四个研究项目， 核心资源和方法有相当多的重叠 和人员，以便进行建设性的互动。 四 项目有：1）“核磁共振成像在肿瘤血管生成”探索 磁化率和其他固有的NMR对比机制， 肿瘤新生血管的体内评估和对 抗血管生成治疗; 2）“心肌细胞的NMR研究” 灌注"测量心肌血流储备 在使用固有T1和T2 * 对比度的动物模型和患者中 3）"核磁共振成像中的磁化率对比" 提供了理论和实验评估，在几个 生物异质性产生可量化的 对比度和核磁共振成像过程的细节是 这对量化潜在的生物学至关重要。 4)核磁共振 受体成像"探索新的受体和免疫特异性 氧化铁造影剂用于体内表征 癌 待检验的总体假设包括：1）磁性 磁化率和其它固有NMR效应可用于 定量评估血流量、血容量并测量 体内血管尺寸密度和2）超顺磁性铁 氧化物颗粒可以靶向肿瘤特异性受体， 用NMR成像进行体内表征。 这些项目 由三个核心实验室、NMR设施、NMR 计算机和技术，以及造影剂核心，并由 行政核心。

This Program Project Grant proposal seeks continued support for research directed toward a more comprehensive understanding and novel applications of magnetic susceptibility and other intrinsic NMR contrast mechanisms that provide in vivo physiological information. This research explores the relationship between microscopic biological compartmentalization and macroscopic NMR image contrast. Though much progress has been made in understanding these phenomena as they pertain to measurements of blood volume and iron biochemistry, many unresolved issues, particularly concerning perfusion, oxygen consumption, and targeting effectiveness remain. A coordinated investigation of these effects is provided to enhance the utilization of MR imaging in a variety of organ systems and pathological states, including cancer and coronary artery disease. The availability of real time echo planar imaging as a tool for the study of these questions continues to offer both new opportunities and scientific challenges. This proposal is divided into four research projects which share Core resources and have considerable overlap of methodologies and personnel to allow for constructive interaction. The four projects are: 1) "NMR Imaging in Tumor Angiogenesis" explores susceptibility and other intrinsic NMR contrast mechanisms for the in vivo assessment of tumor neovascularity and the response to anti-angiogenic therapy; 2) "NMR Studies of Myocardial Perfusion" addresses the measurement of myocardial flow reserve in animal models and patients using intrinsic T1 and T2* contrast mechanisms; 3) "Susceptibility Contrast in NMR Imaging" provides theoretical and experimental assessment in several systems in which biological heterogeneity produces quantifiable contrast and that the specifics of the NMR imaging process are crucial to the quantification of the underlying biology. 4) "NMR Receptor Imaging" explores novel receptor and immunospecific iron oxide contrast agents for the in vivo characterization of cancer. Overall hypotheses to be tested include: 1) that magnetic susceptibility and other intrinsic NMR effects can be used to quantitatively assess blood flow, blood volume and measure the density of vessel size in vivo and 2) that superparamagnetic iron oxide particles can be targeted to tumor specific receptors enabling in vivo characterization with NMR imaging. These projects are supported by three Core laboratories, NMR Facilities, NMR Computer and Technologies, and Contrast Agent Cores, and by an Administrative Core.