SPORE IN BREAST CANCER

这份文件描述了我们的孢子续期申请，标题为“小说 预防和治疗乳腺癌的目标“。这项计划是 基于分子参与有丝分裂、侵袭的前提 乳腺癌的转移行为是可识别的，因此可以 可用于改进预测、治疗选择和设计 用于治疗和预防疾病的特定生物疗法。 在这一应用中，集中了一系列互动研究项目 扩大对这些疾病致病意义的认识 乳腺癌进展中的分子和利用这一信息 开发有效的乳腺癌预防和治疗新策略 治疗。为翻译研究选择的具体目标 包括：肿瘤诱导所需的肝素结合生长因子 血管生成(因此是从原位转化为侵入性的关键 乳腺癌)；由乳腺癌细胞分泌的金属蛋白酶及其 临床前和临床试验中的抑制；镉的探索 作为一种意想不到的雌激素物质，可能与乳房有关 促进癌症；使用移植物抗宿主病由一种新的 自体骨髓移植策略将在中国进行测试 临床前和随机临床试验；策略的发展 使用较新的维甲酸预防乳腺癌；以及鉴定 与激素生长调节有关的关键基因产物 独立乳腺癌及其作为预后或预后指标的潜在应用 治疗靶点。预后的临床前和临床研究 涉及这些乳腺癌基因产物的因素和治疗方法有 概述。描述了五个核心，包括一个新鲜和 冷冻的乳腺肿瘤材料，乳腺癌细胞系的储存库， 临床乳腺癌研究资源，血清和血浆库：，和 支持这些项目的独特研究协调机制 并促进与其他机构优势和其他方面的互动 孢子。致力于教师持续发展的计划 乳腺癌研究以年轻患者为例进行描述 将从该计划中受益的教职员工以及最近 已达到教员级别并受到同行评审的受训人员 为他们的工作寻找。一系列高度优先的试点项目 以及优先排序和监督系统的讨论 直接对主要的孢子项目和翻译项目做出贡献 研究活动。最后，一个连贯、结构严密的组织 因为孢子是描述的，它提供了责任，灵活性和 在孢子内部、在体制结构内的最佳互动， 并与其他孢子一起实现改善女性前景的目标 有患乳腺癌的风险，以及已经患有乳腺癌的患者 疾病。

This document describes our SPORE renewal application entitled "Novel Targets for Prevention and Therapy of Breast Cancer". This program is based on the premise that molecules involved in the mitogenic, invasive and metastatic behavior of breast cancer are identifiable, and thus can be exploited for improved prognostication, therapy selection, and design of specific biologic therapies for treatment and prevention of disease. In this application a series of interactive research projects are focused on expanding our understanding of the pathogenetic significance of these molecules in breast cancer progression and exploiting this information to develop effective new strategies for breast cancer prevention and treatment. Specific targets chosen for translational research studies include: heparin binding growth factors required for tumor induced angiogenesis (and thus critical for conversion from in situ to invasive breast cancer); metalloprotease secreted by breast cancer cells and their inhibition in preclinical and clinical trials; the exploration of cadmium as an unexpected estrogenic substance potentially involved in breast cancer promotion; the use of graft versus host disease induced by a novel autologous bone marrow transplantation strategy to be tested in preclinical and randomized clinical trials; the development of strategies for breast cancer prevention using newer retinoids; and identification of critical gene products involved in the growth regulation of hormone independent breast cancer and their potential use as prognostic or therapeutic targets. Preclinical and clinical studies of prognostic factors and therapies involving these breast cancer gene products are outlined. Five cores are described including a tumor bank of fresh and frozen breast tumor materials, a repository of breast cancer cell lines, clinical breast cancer research resources, a serum and plasma bank:, and a unique mechanism of research coordination which supports these projects and fosters interaction with other institutional strengths and other SPOREs. A program for continued development of faculty committed to breast cancer research is described with specific examples of young faculty who will benefit from this program as well as examples of recent trainees who have achieved faculty rank and attracted peer-reviewed finding for their work. A portfolio of high priority pilot projects together with a system for prioritization and oversight are discussed which contribute directly to major SPORE projects and translational research activities. Finally, a coherent, tightly structured organization for the SPORE is described which provides accountability, flexibility and optimal interaction within the SPORE, within the institutional structure, and with other SPOREs to achieve the goal of improved outlook for women at risk of breast cancer and for patients already suffering from the disease.