CORE--LABORATORY CORE

实验室分析是每一项工作的重要组成部分。 作为本计划项目的一部分提交的个人调查。 因为涉及到的许多分析都是由许多 研究，这项提议的目的是建立一个实验室核心 单位在拟议的计划项目中。中央实验室的使用 CORE将确保获得所有项目研究的可比数据 使用一致的实验室技术在建立的 质量控制指南。 实验室核心将有五个主要职责领域 单位。职责将包括：(1)进行所有氟化物 分析；(2)制备淋巴细胞或骨髓姊妹细胞标本 染色单体交换分析和进行这些分析；(3) 为生化分析提供小组成员和动物样本 Wishard医院的数据，并对这些数据进行汇编和分析 分析；(4)准备所有组织标本；和(5)提供 为国际合作伙伴提供分析、实验室程序方面的培训 参与该计划项目的调查人员。这一核心单位将是 在目前可用的设施中建立，并将配备 具备所需分析技术专业知识的人员。这个 实验室核心单位将认真协调和指导所有实验室 每项研究所需的分析，以确保成功完成 在所有计划调查中。

Laboratory analyses constitute a large and essential part of each individual investigation being submitted as part of this Program Project. Because many of the analyses that are involved are required by numerous studies, the purpose of this proposal is to establish a Laboratory Core Unit in the proposed Program Project. The use of a centralized Laboratory Core will assure that comparable data for all Project studies are obtained using consistent laboratory techniques conducted under established guidelines for quality control. There will be five major areas of responsibility in the Laboratory Core Unit. The responsibilities will include: (1) conducting all fluoride analyses; (2) preparing specimens for lymphocyte or bone marrow sister chromatid exchange (SCE) analyses and conducting these assays; (3) delivering panelist and animal samples for analyses of biochemical parameters at Wishard Hospital, and compiling and analyzing data from those analyses; (4) preparing all histological specimens; and (5) providing training in analytical, laboratory procedures to international co- investigators participating in the Program Project. This Core Unit will be established in currently available facilities and will be staffed by personnel with expertise in the required analytical techniques. The Laboratory Core Unit will carefully coordinate and conduct all laboratory analyses required for each study in order to ensure successful completion of all Program investigations.