EFFECTS OF FLUORIDE IN MEDICALLY COMPROMISED ANIMALS

氟化物对患有疾病的动物的影响

• 批准号: 6238489
• 负责人: ANN J DUNIPACE
• 金额: $ 0.2万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1997-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6238489
• 关键词: blood chemistry; chronic renal failure; dental pharmacology; diabetes mellitus; disease /disorder proneness /risk; environmental toxicology; fluorine; genetic disorder; histopathology; hypocalcemia; laboratory rat; longitudinal animal study; malnutrition; nutrition related tag; pharmacokinetics; protein deficiency; urinalysis; water supply

Extensive experimental and clinical data have established that, at a concentration of approximately 1 ppm in drinking water, fluoride is highly effective in reducing the incidence of dental caries and does not cause adverse clinical responses. However, because of its well-documented cariostatic property, fluoride is increasingly being added to other dental health products, and the resulting increase in exposure of populations to fluoride has renewed consideration of the margin of safety which exists between the safe and toxic levels of fluoride exposure. There is cause for concern particularly in cases where fluoride metabolism may be altered by impaired physiological function. The objective of this study is, therefore, to determine the effects of chronic fluoride exposure on physiologically compromised animals in order to test the hypothesis that, under conditions of aging, metabolic or kidney diseases, or nutritional deficiencies, the biological impact of fluoride increases and the threshold for safe fluoride exposure is decreased. The specific aims of this project will be to monitor fluoride balance, terminal blood and tissue fluoride levels, changes in tissue integrity and function, and genetic alterations in animals chronically exposed to fluoride under conditions of: 1) aging; 2) diabetes; 3) chronic renal failure; and 4) nutritional deficiencies. Changes in the monitored parameters will be measured using biochemical, histological and genotoxic methodologies. If the effects of fluoride are increased, or become toxic, in these higher-risk animal populations and the hypothesis of this study is true, then data from this project will help establish awareness of the need for discriminant use of fluoride by similar high-risk human populations, and will clarify criteria for the safe, public health use of fluoride.

大量的实验和临床数据已经证实，在一个 饮用水中的氟浓度约为1ppm，氟化物含量很高 有效降低龋齿发病率，且不会引起 临床不良反应。然而，由于它有很好的记录 防龋性，氟化物正越来越多地被添加到其他牙科中 保健品，以及由此导致的人群接触的增加 氟化物重新考虑了现有的安全边际 在氟暴露的安全和有毒水平之间。有理由这样做 特别是在氟化物代谢可能被改变的情况下 生理功能受损。这项研究的目的是， 因此，为了确定慢性氟暴露对人类健康的影响 生理受损的动物，以检验这一假设， 在衰老、代谢或肾脏疾病或营养不良的情况下 缺乏，氟的生物影响增加和门槛 对于安全的氟暴露是减少的。这个项目的具体目标是 将监测氟平衡、末梢血和组织氟 水平、组织完整性和功能的变化以及基因改变 在以下条件下长期暴露于氟的动物：1)衰老； 2)糖尿病；3)慢性肾功能衰竭；4)营养不良。 监测参数的变化将使用生化测量， 组织学和遗传毒性方法学。如果氟化物的影响是 在这些高风险动物种群中增加，或变得有毒 这项研究的假设是正确的，那么来自该项目的数据将会有所帮助 建立对歧视使用氟化物的必要性的认识 高危人群，并将明确安全、公开的标准 健康地使用氟化物。