ALCOHOL CONSUMPTION AND LUNG CANCER

这里提出的是一个基于人群的病例对照研究的作用， 酒精摄入在肺癌病因学中的作用。 寿命 饮酒，包括频率、每次饮酒量、饮料 饮酒的类型和环境都将进行评估， 潜在混杂因素：吸烟（终生吸烟史、吸烟频率 和类型），饮食（类胡萝卜素，脂肪，胆固醇和总千卡 被动吸烟暴露（在家中、工作场所和 社会化）和职业史。 此外， 吸烟和饮食与肺癌的风险 将对伊利县和尼亚加拉县进行访谈（560名白色男性，500名白色 女性，165名黑人男性和65名黑人女性）。 控件将被 随机选择，那些年龄在65岁以下的驾驶执照注册者; 65岁及以上的人， 给药，所有频率均与年龄、性别、种族和 居住的县。 对于69岁以下的人，也将使用对照品 在心肌梗死病例对照研究的比较中。 对于所有情况，将至少有两个对照。 访谈资料和血液 将使用样本表格控件来评估 酒精使用和吸烟，被动吸烟， 饮食、职业和血液指标（类胡萝卜素、硒、红细胞 谷胱甘肽过氧化物酶、脂质过氧化物酶（MDA）、维生素A、C和E， 总胆固醇、LDL-胆固醇和HDL-胆固醇）， 一般人口和按种族和性别分类。 这 研究提供了一个重要的机会，有效地审查 酒精和澄清的病因，这一重大公众 健康问题。 此外，关于酒精和其他 一般人群中的风险因素将增加我们对 酒精是慢性病的危险因素。 这些问题可以是 以有效和经济的方式解决， 本部分和心肌研究部分的目的 两项研究中对照组的联合使用 件.

Proposed here is a population-based case-control study of the role of alcohol consumption in the etiology of cancer of the lung. Lifetime alcohol consumption including frequency, quantity per occasion, beverage type and setting of drinking will all be evaluated with control for potential confounders: smoking (lifetime history of amount, frequency and type), diet (carotenoids, fat, cholesterol and total kilocalorie intake), passive smoke exposure (lifetime exposure at home, work an socializing) and occupational history. In addition, interaction of alcohol with smoking and with diet in risk of lung cancer of the lung in Erie and Niagara counties will be interviewed (560 white males, 500 white females, 165 black males and 65 black females). Controls will be randomly selected, those under age 65 from driver's license enrollees; and those 65 and over from enrollment lists for the Health Care Finance Administration, all frequency matched to cases on age, sex, race and county of residence. For those under age 69, controls will also be used in the comparisons for the case-control study of myocardial infarction. For all cases there will be least two controls. Interview data and blood samples form controls will be used to evaluate the relationships between the comprehensive measures of alcohol use and smoking, passive smoking, diet, occupation, and blood measures (carotenoids, selenium, RBC glutathione peroxidase, lipid peroxidase (MDA), vitamins A, C, and E, total cholesterol, LDL-cholesterol and HDL-cholesterol), in a sample of the general population and by race-and sex-specific categories. This study provides an important opportunity for an efficient examination of alcohol and clarification of the etiology of this significant public health problem. Additionally, data on distribution of alcohol and other risk factors in the general population will add to our understanding of alcohol as a risk factor in chronic disease. These questions can be addressed in a valid and economical way by combining several specific aims in this component and the research component on myocardial infarction and the combined use of the controls in the two research components.