AM/500 NMR CONSOLE UPGRADE

布鲁克AM-500核磁共振仪（NMR）的控制台升级 光谱仪提出。这一升级后的仪器将可用于 11个主要用户在24小时的基础上，为他们的NIH资助 问题研究升级后的500兆赫核磁共振将继续作为一个 为主要用户和研究界提供部门服务， 科罗拉多州立大学。新的控制台将提供给主要用户 提高了灵敏度，更方便地获得直接检测 的NMR核作为新的双宽带探针的结果。新 控制台将减少噪音，增加稳定性，改善 动态范围，两个通道中的RF控制的显著改进， 精确的温度控制，灵活的观察和解耦 功能，z轴梯度增强光谱，选择性 激励、整形脉冲和多个同时（多路复用）区域 选择性脉冲既有最先进的新技术， (but这些技术将得到极大的改进。 NIH支持的研究，包括各种一维和多维 梯度增强方法（例如，GOESY、NOESY、HSQC、HMBC、MQFCOSY和 这些实验的各种连字符版本），宽带信道 解偶联，H2O中的生物分子NMR，其他质子中的NMR研究， 溶剂，旋转框架实验（例如，罗西，托西。HoHAHA），以及 选择性脉冲实验

A console upgrade for a Bruker AM-500 nuclear magnetic resonance (NMR) spectrometer is proposed. This upgraded instrument will be available to the eleven major users on a twenty-four hour basis for their NIH-funded studies. The upgraded 500 MHZ NMR will continue to be operated as a departmental service to the major users and the research community at Colorado State University. The new console will offer to the major users increased sensitivity and more convenient access to the direct detection of NMR nuclei as the result of the new dual-broadband probe. The new console will have reduced noise, increased stability, improved dynamic range, dramatic improvements to RF control in both channels, precise temperature control, flexible observe and de-couple capabilities, z-axis gradient enhanced spectroscopy, selective excitation, shaped pulses and multiple simultaneous (multiplexed) region selective pulses. Both new, state-of-the-art techniques and well-proven (but dramatically improved) techniques will be available for these NIH-supported studies, including various one and multi-dimensional gradient-enhanced methods (e.g., GOESY, NOESY, HSQC, HMBC, MQFCOSY and various hyphenated versions of these experiments), broadband channel de-coupling, bio-molecular NMR in H2O, NMR studies in other protio- solvents, rotating frame experiments (e.g., ROESY, TOCSY. HoHAHA), and selective pulse experiments.