CORE--FIELD AND CLINIC OPERATIONS

核心A的目标是找到并重新检查至少750个 圣安东尼奥家庭心脏研究的最初参与者， 占1，250名原住民的60%， 在圣安东尼奥方圆200英里范围内 基线检查（1，119名参与者居住在城市范围内 （圣安东尼奥）。这些人将被仔细检查， 可能到他们基线检查的第六周年。 我们 将重新采访这些人，以更新他们的 人口统计数据和病史，我们还将重新- 管理半定量食物频率问卷和7- 日体力活动回忆，以更新饮食和体力活动 活动信息。 我们将进行葡萄糖耐量试验， 胰岛素测量，我们还将获得空腹血 分发给其他参与实验室的样本 用于脂质、脂蛋白和血栓形成/纤维蛋白溶解测量。 最后，我们将进行超声检查，以获得 颈总动脉和颈内动脉壁内膜中层测量 厚度。 我们将继续实施质量控制 在本赠款期内制定的程序， 数据收集、样本处理和数据输入 电脑 我们将对饮食和 身体活动原始数据并将提供给所有共同研究者 包含人口统计学，病史，行为， 体格检查和葡萄糖耐量数据。

The objective of Core A is to locate and re-examine at least 750 of the original participants of the San Antonio Family Heart Study, representing 60% of the 1,250 original participants who resided within a 200 mile radius of San Antonio at the time of their baseline examination (1,119 participants lived within the city limits of San Antonio). These individuals will be examined as close as possible to the 6th anniversary of their baseline examination. We will re-interview these individuals in order to update their demographic data and medical history and we will also re- administer a semiquantitative food frequency questionnaire and a 7- day physical activity recall in order to update dietary and physical activity information. We will perform a glucose tolerance test with insulin measurements and we will also obtain fasting blood specimens to be distributed to the other participating laboratories for lipid, lipoprotein, and thrombosis/fibrinolysis measurements. Finally, we will perform ultrasonography examinations to obtain measurements of common and internal carotid wall intima-media thicknesses. We will continue to apply the quality control procedures developed during the present grant period which pertain to data gathering, specimen handling, and data entry into the computer. We will perform data reduction on the dietary and physical activity raw data and will provide to all co-investigators computer files containing demographic, medical history, behavioral, physical examination, and glucose tolerance data.