NEUROLOGICAL STUDIES

这项工作的总体目标是进一步了解 正常成人大脑的功能组织。 这样的 由于两个原因，这项工作是可行的，（1）PET可以测量 正常人脑的小区域中的血流具有一定程度的 准确性无与伦比的任何其他技术和（2）改变当地 血流量准确地反映了局部集合体活动的变化 的神经元。 脉管系统提供了一个独特的“窗口， 的大脑”。 使用PET测量局部脑血流量，我们将 (1)识别人类大脑皮层中的多个感觉区域， 个体受试者与其MRI定义的解剖结构的关系;（2）定义， 至少粗略地，这些地区的地形组织;（3）测试 刺激，其将用于识别 大脑皮层;（4）确定更复杂的功能，如语言， （5）测试这些主要区域之间的关系; 初级感觉区的功能与解剖标志;如果 解剖和功能之间没有紧密的关系， 地标，（6）测试使用功能地标作为3- - 维扭曲算法，以便增强信号平均， 跨学科的功能图比较。

The overall objective of this work is to further our understanding of the functional organization of the normal adult human brain. Such an undertaking is feasible for two reasons, (1) PET can measure changes in blood flow in small regions of the normal human brain with a degree of accuracy unsurpassed by any other technique and (2) changes in local blood flow accurately reflect changes in the activity of local ensembles of neurons. The vasculature provides a unique "window to the workings of the brain". Using PET measurements of local brain blood flow we will (1) identify multiple sensory areas in the human cerebral cortex of individual subjects in relation to their MRI-defined anatomy; (2) define, at least coarsely, the topographic organization of these areas; (3) test stimuli which will serve to identify functional landmarks within the cerebral cortex; (4) determine how more complex functions like language are mapped on to these principal areas; (5) test the relationship of functional vs anatomical landmarks in primary sensory areas; and, if there is not a tight relationship between anatomical and functional landmarks, (6) test the use of functional landmarks as constraints in 3- dimensional warping algorithms in order to enhance signal averaging and comparisons of functional maps across subjects.