MULTIMODALITY FUNCTIONAL BRAIN IMAGING

脑功能成像是基于这样一种假设 脑循环局部改变(即血液流动、血液 体积、血管平均通过时间)和代谢 反映神经元活动的变化。正电子发射断层扫描 (PET)和磁共振成像(MRI)能够测量 循环和代谢的变化安全和准确地 为了解人脑功能提供了一个独特的窗口。然而，我们的 认识脑循环与中医辨证论治的关系 新陈代谢到神经元活动是不完整的，我们的 对正电子发射计算机断层扫描和核磁共振成像在脑梗塞中各自作用的认识 调查这些问题。这个项目的目的是 将PET、MRI和磁共振波谱(MRS)结合使用 在正常人和特定疾病患者中 为了更全面地了解 获得的信号以及正电子发射计算机和电子计算机各自应发挥的作用 磁共振成像在脑功能成像中的应用。这个项目是对在 《权力的计划》详细探讨了 脑功能对药物的传递、转运和代谢的影响 葡萄糖。该项目对中国的工作也很重要。 彼得森的项目，其中核磁共振的作用尚未确定。 最后，这个项目汇集了专业知识和资源 三个主要研究小组的联合经验在功能 用PET(Raichle An Power)、MRI(Haacke和Lin)进行脑成像 而夫人(阿克曼、尼尔和布雷索斯特)是独一无二的，应该确保 关于人脑的重大科学信息 将从拟议的研究中获得新的功能。

Functional brain imaging is based upon the assumption that localized changes in brain circulation(i.e., blood flow, blood volume, vascular mean transit time) and metabolism accurately reflect changes in neuronal activity. Positron emission tomography (PET) and magnetic resonance imaging (MRI) are able to measure changes in circulation and metabolism safely and accurately to provide a unique window into human brain function. However, our understanding of the relationship of brain circulation and metabolism to neuronal activity is incomplete as is our understanding of the respective roles of PET and MRI in investigating these issues. It is the purpose of this project to employ PET, MRI and magnetic resonance spectroscopy (MRS) together in normal human subjects as well as patients with selected diseases to obtain a more complete understanding of the basis for the signals obtained and the respective role to be played by PET and MRI in functional brain imaging. This project compliments work in the project by powers which explores in detail the relationship of brain function to the delivery, transport and metabolism of glucose. This project will also be important to the work in the project by Peterson where the role of MRI has yet to be determined. Finally, this project brings together the expertise and resources of 3 major research groups whose combined experience in functional brain imaging with PET (Raichle an Powers), MRI (Haacke and Lin) and MRS (Ackerman, Neil and Bretthorst) is unique and should ensure that significant new scientific information regarding human brain function will be forthcoming from the proposed studies.