PILOT STUDY--INFLUENCES ON INJURY OUTCOME AFTER MASSIVE TRANSFUSION

这项前瞻性的先导性研究旨在探索这种关系 与损伤相关的生理、免疫和心理变量之间的关系 以及与伤害相关的具体后果。指导研究的问题 本研究主要研究内容如下：1.伤害类型、伤害类型、伤害类型对学生心理健康的影响 创伤后的严重程度和免疫状态对生存的影响 需要大量输血吗？和2.类型的影响是什么？ 受伤、受伤严重程度、免疫状态和心理困扰 住院时间、并发症数量和功能恢复情况？一个 样本25人，遭受创伤性损伤需要更多 在接下来的24小时内超过10个单位的红细胞 受伤将被纳入这项研究。主题将被跟踪 纵向观察3个月。数据将被收集：受伤后 开始复苏前(T1)、2天(T2)、7天(T3)、1个月 T4)和3个月(T5)。收集的数据包括静脉血样 免疫表型(T1、T2、T3、T5)和肝炎血清学(T1、T4、T5)； 存活率、并发症、住院时间(T5的图表审核)；类型 来自计算机创伤登记处的伤害和伤害严重程度(T5)；以及 心理困扰的结构化访谈(T3、T4、T5)和 功能恢复(T5)。将使用描述性方法分析数据 统计和双变量分析。这项初步研究的结果将 提供初步数据以确定大规模的可行性 创伤对生理、免疫和心理影响的研究 危及生命的伤害后某些结果的变量 需要大量输血。后续的研究将集中在 开发和测试跨学科干预措施，以改进 生存，最大限度地减少继发并发症，控制住院时间和 成本，并在危及生命的情况下加强功能恢复 受伤。

This prospective pilot study is designed to explore the relationship between injury-related physical, immunologic, and psychologic variables and specific injury-related outcomes. The research questions guiding this study are: 1. What is the influence of type of injury, injury severity, and immune status on survival following traumatic injury requiring massive transfusion? and 2. What is the influence of type of injury, injury severity, immune status, and psychological distress on length of stay, number of complications, and functional recovery? A sample of 25 individuals, sustaining traumatic injury requiring greater than 10 units of packed red blood cells within the first 24 hours after injury will be enrolled in the study. Subjects will be followed longitudinally for 3 months. Data will be collected: after injury but before resuscitation commences (T1), 2 days (T2), 7 days (T3), 1 month T4), and 3 months (T5). Data collected includes venous blood samples fo immune phenotypes (T1, T2, T3, T5) and hepatitis serology (T1, T4, T5); survival, complications, length of stay (chart audit at T5); type of injury and injury severity from computerized trauma registry (T5); and structured interviews for psychological distress (T3, T4, T5) and functional recovery (T5). Data will be analyzed using descriptive statistics and bivariate analysis. Results from this pilot study will provide preliminary data to determine the feasibility of a large scale study of the influence of injury-related physical, immune and psychologi variables on selected outcomes following life-threatening injury requiring massive transfusion. Subsequent studies will focus on the development and testing of interdisciplinary interventions to improve survival, minimize secondary complications, control length of stay and costs, and enhance functional recovery following life-threatening injuries.