BORRELIA BIND TO PERIPHERAL BLOOD FIBROCYTES: CONNECTIVE TISSUE TARGETING

伯氏杆菌靶向连接蛋白的分子机制 组织和引起关节炎的原因还不清楚。它已经被证明了 伯氏杆菌对胶原组织有嗜好，可以 与纤维连接蛋白和细胞胶原蛋白相互作用。螺旋体可以 结合许多不同类型的细胞，包括成纤维细胞。 最近，Bucala et al.(摩尔。地中海医院。1：71)描述了一种循环 成纤维细胞样的白细胞称为外周血成纤维细胞。 这些细胞表达I型和III型胶原以及 纤维连接蛋白可能在伤口愈合中发挥作用。纤维细胞也 具有将病原体靶向结缔组织的潜力。我们 推测伯氏杆菌与这类新的 白细胞可能是螺旋体作为靶标的一种机制 去戒毒所。最近的证据表明，伯氏杆菌确实如此。 拥有捆绑和穿透人类和猴子的能力 (恒河猴)体外培养成纤维细胞。这种相互作用的潜力 伯氏杆菌的结缔组织靶向，以及可能的其他 病原体，既耐人寻味，又影响深远。这个 伯氏杆菌靶向结缔组织的分子机制 并导致关节炎的原因尚不清楚。研究表明，B. 伯格多费菌对胶原组织有嗜好，并可以相互作用 纤维粘连蛋白和细胞胶原蛋白。螺旋体可以结合到 许多不同类型的细胞，包括成纤维细胞。最近， 布卡拉等人。(摩尔。地中海医院。1：71)描述了一种循环 成纤维细胞样的白细胞称为外周血成纤维细胞。 这些细胞表达I型和III型胶原以及 纤维连接蛋白可能在伤口愈合中发挥作用。纤维细胞也 具有将病原体靶向结缔组织的潜力。我们 推测伯氏杆菌与这类新的 白细胞可能是螺旋体作为靶标的一种机制 去戒毒所。最近的证据表明，伯氏杆菌确实如此。 拥有捆绑和穿透人类和猴子的能力 (恒河猴)体外培养成纤维细胞。这种相互作用的潜力 伯氏杆菌的结缔组织靶向，以及可能的其他 病原体，既耐人寻味，又影响深远。

The molecular mechanisms of how B. burgdorferi targets connective tissues and causes arthritis is not understood. It has been shown that B. burgdorferi has a predilection for collagenous tissue and can interact with fibronectin and cellular collagens. The spirochetes can bind to a number of different cell types, including fibroblasts. Recently, Bucala et al. (Mol. Med. 1:71) described a circulating fibroblast-like leukocyte called the peripheral blood fibrocyte. These cells, which express collagen types I and III as well as fibronectin, may play a role in wound healing. Fibrocytes also possess the potential to target pathogens to connective tissue. We speculated that binding of B. burgdorferi to this novel class of leukocytes may represent one mechanism by which the spirochete targets to the joint. Recent evidence demonstrats that B. burgdorferi does possess the ability to bind and penetrate both human and monkey (rhesus) fibrocytes in vitro. The potential of this interaction for connective tissue targeting of B. burgdorferi, and potentially other pathogenic organisms, is both intriguing and far reaching. The molecular mechanisms of how B. burgdorferi targets connective tissues and causes arthritis is not understood. It has been shown that B. burgdorferi has a predilection for collagenous tissue and can interact with fibronectin and cellular collagens. The spirochetes can bind to a number of different cell types, including fibroblasts. Recently, Bucala et al. (Mol. Med. 1:71) described a circulating fibroblast-like leukocyte called the peripheral blood fibrocyte. These cells, which express collagen types I and III as well as fibronectin, may play a role in wound healing. Fibrocytes also possess the potential to target pathogens to connective tissue. We speculated that binding of B. burgdorferi to this novel class of leukocytes may represent one mechanism by which the spirochete targets to the joint. Recent evidence demonstrats that B. burgdorferi does possess the ability to bind and penetrate both human and monkey (rhesus) fibrocytes in vitro. The potential of this interaction for connective tissue targeting of B. burgdorferi, and potentially other pathogenic organisms, is both intriguing and far reaching.