COMPREHENSIVE CENTER DEVELOPMENTAL GRANT--U AT BUFFALO

这笔发展助学金的目的是支持 国家发现型口腔综合研究中心 纽约大学布法罗分校。拟建的中心将解决 口腔和全身健康的相互作用。最初，我们建议 调查人类的重大慢性致残性疾病和疾病 如糖尿病、心血管疾病和骨质疏松症，以及他们的 与口腔感染的关系，如牙周病。基本信息 生物医学研究、卫生服务研究、教育研究和 技术转让活动将针对这一中心主题。 具体目标是：i)发展基本的生物医学和行为学 口腔和全身健康的研究基地。2)发展 用于示范、外展和社区的卫生服务研究 联络职能。3)开展健康教育研究，促进 并通过以下方式管理旨在促进科学转移的研究 教育。4)加强和赞扬技术转让活动 更有效地翻译与口腔和全身健康相关的发现 去练习。5)发展行政和行政基础设施 研究支持核心，以确保日常支持和运营，以及 监督和评估中心的活动，以确保有效 从事翻译研究的科学家之间的合作。 全身疾病和口腔感染之间的强烈相互作用， 例如牙周病，都是最近建立的。为 例如，牙周病的危险因素包括全身性 条件和习惯，如吸烟、糖尿病、艾滋病，可能 骨质疏松症和压力。一系列新的研究支持这一概念 口腔感染，如牙周病，增加了严重程度 指系统性疾病，如糖尿病；可能解释了一些 无法解释的心血管疾病、中风和低出生风险 体重递送；并且可能是呼吸道的一个重要来源 病原体。 对这些重要相互作用的全面研究不仅将 可能会带来更好的口腔健康，但也可能表现出 对全身健康的影响。布法罗大学牙学院 医学拥有一支强大、成熟的口腔健康研究团队， 与生物医学同事现有的富有成效的合作 糖尿病、妇女健康、心血管疾病和呼吸系统疾病 感染。这为一个重要的翻译时代奠定了基础 以布法罗大学为中心的研究，将应用这一点 酌情掌握实践保健环境的知识：2000和 更远一点。

The objective of this Developmental Grant is to support the planning of a Comprehensive Oral Heal Research Center of Discovery at the State University of New York at Buffalo. The proposed Center will address the interactions of oral and systemic health. Initially, we propose to investigate major chronic, disabling disease and disorders of mankind such as diabetes, cardiovascular disease, and osteoporosis, and their relationship to oral infections such as periodontal disease. Basic biomedical studies, health services research, education studies, and technology transfer activities will be directed to this central theme. Specific Aims are: I) To develop a basic biomedical and behavioral research base which addresses oral and systemic health. 2) To develop health services research for demonstration, outreach and community liaison functions. 3) To develop health education research to facilitate and manage research directed to facilitate science transfer through education. 4) To enhance and compliment technology transfer activities to more effectively translate oral and systemic health-related findings to practice. 5) To develop the infrastructure for administrative and research support cores to ensure day-to-day support and operation, and to monitor and evaluate Center activities to ensure effective collaborations among scientists engaged in translational research. Strong interactions between systemic conditions and oral infections, such as periodontal disease, have recently been established. For example, risk factors for periodontal diseases include general systemic conditions and habits, such as smoking, diabetes, AIDS, and possibly osteoporosis and stress. A new series of studies supports the concept that oral infections, such as periodontal disease, increase the severity of systemic diseases such as diabetes mellitus; may account for some of the unexplained risk of cardiovascular disease, stroke, and low birth weight deliveries; and may be an important source of respiratory pathogens. Comprehensive studies of these important interactions will not only likely lead to better oral health, but may also demonstrate major effects on systemic health. The University at Buffalo School of Dental Medicine has a strong, well-developed oral health research team with existing productive collaborations with biomedical colleagues in diabetes, women's health, cardiovascular disease, and respiratory infections. This sets the stage for an era of important translational research, centered at the University at Buffalo, which will apply this knowledge, as appropriate, to practice settings for Health: 2000 and beyond.