ALZHEIMERS DISEASE CENTER CORE

许多科学上的进步已经在研究 阿尔茨海默病（AD）是由于两个可用性以及 特征的AD患者和他们的组织， 临床科学家和基础科学家之间。 大学里的AD研究 在伯明翰的亚拉巴马州的一所学校就是在这种模式下培养起来的。 在过去， 不同的科学学科通过该计划走到了一起 项目和R 01格式来研究这种独特的人类疾病。 的 阿尔茨海默病中心核心（ADCC）是下一个被提议的 我们在这所大学研究AD的逻辑进展，因为它将 增加研究的机会，进一步团结我们的努力，研究 协助招聘新的调查员，并加强 通过提供新的教育机会，提高AD相关问题的可见度。 拟议中的ADCC由四个核心组成：行政， 临床、神经病理学和信息传输。 行政 核心将为规划和 实施所有旨在实现ADCC的活动 目标. 在这一核心框架内，规定了具体的监督机制， 和监测ADCC活动，质量保证，预算管理， 招聘新的调查员。 后一个目标反映在 提交的试点项目，调查基础科学（即， 扣带皮层解剖学;钠通道）和临床（口腔 沟通;能力）与AD相关的问题。 临床核心将 作为所有大学调查人员的资源， 每年纵向评估50例轻度痴呆AD患者， 招募25名正常黑人受试者， 年 此外，该核心还将开始评估 在AD中发生的干扰以及帮助获得组织， 神经病理学核心，提供患者档案管理和生物统计 服务 神经病理学核心也将作为资源， 大学研究人员通过获取和提供CNS组织， AD，正常老年人和年轻人，提供特定诊断 临床核心随访的患者，评估颞叶病理学 在AD患者中，并作为解剖和 免疫细胞化学技术。 信息传输核心将提供 ADCC的教育部分，提供多种教育 为公众和卫生专业人士开展的活动。 具体而言是 黑人社区和家庭实践，内科医生和全科医生 将成为目标。 在UAB实施ADCC将进一步团结 我们的特定社区将其全部资源投入飞行 来战胜这种叫做阿尔茨海默病的毁灭性疾病。

Many of the scientific advances that have been made in the study of Alzheimer's Disease (AD) have been due to both the availability of well characterized AD patients and their tissue and to the collaborative efforts between clinical and basic scientists. The study of AD at the University of Alabama at Birmingham has been fostered on this model. In the past, disparate scientific disciplines have come together through the Program Project and R01 format to study this uniquely human illness. The Alzheimer's Disease Center Core (ADCC) which is proposed is the next logical progression for our study of AD at this University, as it would multiply the opportunities for research, further unite our efforts to study AD, and aid in the recruitment of new investigators, and enhance the visibility of AD related issues by allowing new educational opportunities. The ADCC, as proposed, is composed of four Cores: Administrative, Clinical, Neuropathology, and Information Transfer. The Administrative Core will provide the organizational base for the planning and implementation of all activities directed toward the fulfillment of ADCC goals. Within this Core, specific mechanisms are provided for overseeing and monitoring ADCC activities, quality assurance, budgetary management, and recruitment of new investigators. The latter goal is reflected in the submitted Pilot Projects, which investigate both basic science (i.e., cingulate cortex anatomy; sodium channels) and clinical (oral communication; competency) issues relevant to AD. The Clinical Core will serve as a resource for all University investigators by recruiting and longitudinally assessing 50 mildly demented AD patients per year and by the recruitment and longitudinal evaluation of 25 normal Black subjects per year. Additionally, this Core will also begin to assess the behavioral disturbances occurring in AD as well as help acquire tissue for the Neuropathology Core and provide patient file management and biostatistical services. The Neuropathology Core will also serve as a resource for University investigators by acquiring and making available CNS tissue and AD, normal older and younger individuals, providing specific diagnoses on patients followed in the Clinical Core, assessing temporal lobe pathology in AD patients, and serving as a resource unit for anatomical and immunocytochemical techniques. The Information Transfer Core will provide the educational component of the ADCC by providing multiple educational activities for the lay public and health professions. Specifically, the Black community and family practice, internists and general practitioners will be targeted. The implementation of an ADCC at UAB will further unite our specific community to bring to bear its full resources into the flight to conquer this devastating illness called Alzheimer's Disease.