课题基金 / 基金详情

ORAL AND IV NAVELBINE (VINORELBINE) IN PEDIATRIC CANCER PATIENTS

ORAL AND IV NAVELBINE (VINORELBINE) IN PEDIATRIC CANCER PATIENTS
小儿癌症患者口服和静脉注射长春瑞滨（长春瑞滨）
批准号：
6244586
负责人：
RAYMOND J HUTCHINSON
金额：
$2.22万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-20 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6244586
关键词：
antineoplastics child (0-11) clinical research clinical trial phase I drug screening /evaluation human subject human therapy evaluation intravenous administration neoplasm /cancer chemotherapy oral administration pediatric neoplasm /cancer pediatric pharmacology vinca alkaloids

项目摘要

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相关文献

中文摘要
翻译
CCG-0936是诺维本的1期儿科试验，诺维本是一种独特的半 一种合成的长春花生物碱，与其他长春花的不同之处在于， 长春质环而不是文多灵环结构被修饰。 这种结构变化赋予药理学特性， 转化为治疗人类癌症的临床效益。
英文摘要
CCG-0936 is a phase 1 pediatric trial of Navelbine, a unique semi- synthetic vinca alkaloid which differs from other vincas in that the catharanthine ring rather than the vindoline ring structure is modified. This structural change imparts pharmacologic properties which may translate into clincal benefits in the treatment of human cancers.
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