ABNORMAL VITAMIN B6 STATUS IN SYSTEMIC LUPUS ERYTHEMATOSUS

最近的研究表明，红细胞增多症(HC)的升高 水平是中风、冠状动脉疾病的危险因素， 外周血管疾病。HC水平在很大程度上由 三种水溶性维生素：叶酸、B12和B6的水平 (吡哆醛-5‘-磷酸，PLP)。我们最近证明了PLP 类风湿性关节炎(RA)患者中的水平低于 年龄匹配的对照组，PLP水平与 这些患者的单个核细胞产生的肿瘤坏死因子(1)。 在最近完成的第二项研究中，我们发现类风湿关节炎患者和 低循环PLP水平升高的HC和AN 口服剂量的Hc激发后HC异常升高 蛋氨酸。这些结果表明，类风湿关节炎患者可能有组织 PLP缺乏并有发生血管并发症的风险 HC升高。

Recent studies have demonstrated that elevation of erum homocytosis (HC) levels is a risk factor for stroke, coronary artery disease, and peripheral vascular disease. HC levels are largely controlled by the levels of three water-soluble vitamins; folate, B12, and B6 (pyridoxal-5'-phosphate, PLP). We have recently demonstrated that PLP levels are low in patients with rheumatoid arthritis (RA) compared to age-matched controls, and that PLP levels correlate with production of tumor necrosis factor (TNF) by mononuclear cells from these patients (1). In a second recently completed study, we found that patients with RA and low circulating PLP levels had elevated fasing levels of HC and an abnormally high increase in HC after challenge with an oral dose of methionine. These results indicate that patients with RA may have tissue deficiency of PLP and be at risk for the vascular complications of elevated HC.