课题基金 / 基金详情

PLACEBO-CONTROLLED SAFETY AND EFFICACY STUDY OF AMINOGUANIDINE IN DIABETES

PLACEBO-CONTROLLED SAFETY AND EFFICACY STUDY OF AMINOGUANIDINE IN DIABETES
氨基胍治疗糖尿病的安慰剂对照安全性和有效性研究
批准号：
6245661
负责人：
TREVOR J. ORCHARD
金额：
$1.76万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-03-18 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6245661
关键词：
aminoguanidine blood chemistry chemoprevention clinical research crosslink diabetes mellitus therapy diabetic nephropathy drug adverse effect drug screening /evaluation glycation human subject human therapy evaluation insulin dependent diabetes mellitus kidney disorder chemotherapy kidney function pharmacokinetics urinalysis

项目摘要

项目成果

TREVOR J. ORCHARD的其他基金

相似基金

相关文献

中文摘要
翻译
本试验的主要目的是评估安全性和有效性 氨基胍对胰岛素依赖患者肾功能的保护作用 依赖性糖尿病和显性糖尿病肾病。 中学; 1）评估氨基胍对蛋白质交联的影响， 通过循环血液和尿液浓度测量的糖尿病患者 晚期糖化终产物（AGEs），2）评估 血浆氨基胍浓度与原发性和继发性 疗效终点以及不良事件
英文摘要
The primary objective of this trial is to evaluate the safety & efficacy of aminoguanidine in preserving renal function in patients with insulin dependent diabetes mellitus & overt diabetic nephropathy. Secondary; 1)to evaluate the effect of aminoguanidine on protein crosslinking in diabetic pts as measured by circulating blood and urinary concentrations of advanced glycated endproducts (AGEs),2) to evaluate the relationship between plasma aminoguanidine concentrations and primary and secondary efficacy endpoints as well as adverse events
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Health system based clinical trial recruitment
Evaluation of Differing Type 1 Diabetes Regimens in Youth in the Developing World
Epidemiology of Diabetes Complications (EDC) Phase II: renewal
Cardiovascular Epidemiology Training Program
海外基金