MAXILLARY SINUS TREATMENTS IN PATIENTS WITH ANTROSTOMIES

囊性纤维化（CF）是一种常见的遗传性疾病，其特征在于： 上皮氯离子转运缺陷和进行性致死性肺 疾病 慢性鼻窦炎，约占CF的50% 患者，在斯坦福大学接受治疗， 上颌窦造口放置，然后每月上颌窦妥布霉素 灌洗。 本方案共入组了4例患者， 上颌窦治疗的评价 上颌窦造口 这项随机、双盲比较的上颌 窦妥布霉素灌洗与安慰剂的比较旨在记录 妥布霉素灌洗的有效性和确定鼻窦炎的发生率 复发 鼻粘膜跨上皮电位差是 类似于上颌窦跨上皮电位差，除了 上颌窦跨上皮电位差， 基线测定，对当地的影响更敏感， 慢性感染

Cystic Fibrosis (CF) is a common genetic disorder characterized by defective epithelial chloride transport and progressive, lethal lung disease. Chronic sinusitis, which plagues approximately 50% of CF patients, is treated at Stanford with a combination of maxillary antrostomy placement followed by monthly maxillary sinus tobramycin lavage. A total of four patients have been enrolled in this protocol, an evaluation of maxillary sinus treatments in patients with antrostomies. This randomized, double blind comparison of maxillary sinus tobramycin lavage versus placebo is designed to document the effectiveness of tobramycin lavage and determine the rate of sinusitis recurrence. Nasal mucosa tranepithelial potential differences are similar to maxillary sinus transepithelial potential differences, except that maxillary sinus tranepithelial potential differences, during baseline determinations, are more sensitive to the effects of local chronic infection.