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EFFECT OF LOW CALORIE DIETS ON GLUCOSE/LIPID METABOLISM IN NIDDM

EFFECT OF LOW CALORIE DIETS ON GLUCOSE/LIPID METABOLISM IN NIDDM
低热量饮食对 NIDDM 葡萄糖/脂质代谢的影响
批准号：
6246341
负责人：
RICHARD M CARROLL
金额：
$2.71万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-01-06 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6246341
关键词：
adipose tissue clinical research diabetes mellitus therapy diet therapy glucose metabolism human subject human therapy evaluation lipid metabolism noninsulin dependent diabetes mellitus nutrition related tag obesity tumor necrosis factor alpha

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中文摘要
翻译
本研究将考察短期（14天）效果极低
英文摘要
This study will examine the effect of short term (14 day) very low calorie diet therapy (VLCD)(420 kCal/day) in patients with upper body obesity and NIDDM. Sensitivity to insulin will be evaluated by euglycemic hyperinsulinemic clamp with stable isotope tracer infusion and the sensitivity of adipose tissue to epinephrine will be studied before/after VLCD therapy. Adipose tissue TNF will be measured by Northern blot analysis of adipose tissue biopsies. We hypothesize VLCD therapy will increase sensitivity of adipose tissue to insulin, normalize sensitivity to epinephrine and reduce production of TNF alpha by adipose tissue.
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会议论文
GLUCOSE AND LIPID METABOLISM IN NIDDM--EFFECTS OF VERY LOW CALORIE DIETS
APOLIPOPROTEINS AND RISK OF CORONARY DISEASE
APOLIPOPROTEINS AND RISK OF CORONARY DISEASE
  • 批准号：
    3448771
  • 项目类别：
  • 资助金额：
    $5.16万
  • 财政年份：
    1984
  • 负责人：
    RICHARD M CARROLL
  • 依托单位：
    AUGUSTA UNIVERSITY
APOLIPOPROTEINS AND RISK OF CORONARY DISEASE
  • 批准号：
    3448772
  • 项目类别：
  • 资助金额：
    $1.68万
  • 财政年份：
    1984
  • 负责人：
    RICHARD M CARROLL
  • 依托单位：
    AUGUSTA UNIVERSITY
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