REAGENT RESOURCE SUPPORT FOR AIDS VACCINE DEVELOPMENT

本合同的目标集中在生产、采购、 质量评估和研究试剂的分发，以支持 DAIDS资助的艾滋病毒疫苗开发。 1-通过购买或其他安排获得，然后描述 供分发的病毒基因产品(如HIV-1、SIV)的数量 由DAIDS支持的调查人员使用。 2-获得并鉴定免疫佐剂、免疫调节剂和 用于实验性艾滋病毒疫苗配方的疫苗输送系统。 3-生产工作数量的专门病毒基因产品或其他 不容易通过购买获得的试剂。 将逆转录病毒基因克隆到合适的原核表达载体中 并对这些载体和基因进行质量保证测试 应项目官员的要求。 5-制备杂交瘤和单抗并鉴定为 应项目官员的要求。 6-维持试剂和库存的电子库存和数据库 所有试剂分析结果中。 根据需要维护和分发所有库存和试剂，并保持 一种跟踪系统，在该系统中，任何给定的样品都可以从接收到的地方进行追踪 通过加工、储存和配送。

The objectives of this contract focus on the production, procurement, quality assessment, and distribution of research reagents in support of DAIDS-funded HIV vaccine development. 1 - Acquire by purchase or other arrangement and then characterize quantities of viral gene products (e.g., HIV-1, SIV) for distribution for use by DAIDS-supported investigators. 2- Acquire and characterize immunologic adjuvants, immunomodulators, and vaccine delivery systems for use in experimental HIV vaccine formulations. 3- Generate working quantities of specialized viral gene products or other reagents not readily available through purchase. 4- Clone retroviral genes into appropriate prokaryotic expression vectors and perform quality assurance testing of these vectors and genes as required by the Project Officer. 5- Prepare and characterize hybridomas and monoclonal antibodies as required by the Project Officer. 6- Maintain an electronic inventory of reagents and stock and a database of all reagent analysis results. 7- Maintain and distribute all stocks and reagents as required and keep a tracking system in which any given sample can be traced from receipt through processing, storage and distribution.