课题基金 / 基金详情

SPECT IMAGING OF DOPAMINE FUNCTION IN BIPOLAR DISORDER

SPECT IMAGING OF DOPAMINE FUNCTION IN BIPOLAR DISORDER
双相情感障碍多巴胺功能的 SPECT 成像
批准号：
6116057
负责人：
Amit Anand
金额：
$3.45万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6116057
关键词：
amphetamines bioimaging /biomedical imaging bipolar depression clinical research dopamine dopamine receptor human subject iodine lithium neurochemistry neurotransmitter transport radiotracer single photon emission computed tomography synapses

项目摘要

项目成果

Amit Anand的其他基金

相关文献

中文摘要
翻译
安非他明(Amph)诱导双相情感障碍多巴胺(DA)释放的研究将探索突触前多巴胺释放机制的异常以及突触后DA受体的研究。这项研究的总体目的是评估目前在情绪稳定剂锂上稳定的双相情感障碍住院患者amph挑战的潜在神经化学相关性。双相情感障碍患者和年龄、性别和种族血统匹配的健康对照组将接受D2示踪剂[123I]IBZM的SPECT试验。
英文摘要
The study of amphetamne (AMPH) induced dopamine (DA) release in bipolar disorder will explore abnormalities in presynaptic dopamine release mechanisms as well as study post-synaptic DA receptors. The general aim of this study is to evaluate potential neurochemical correlates of AMPH challenge inpatients with bipolar disorder currently stable on the mood stabilizer--lithium. Patients with bipolar disorder and healthy controls matched for age, sex and ethnic origin will undergo one SPECT experiment with the D2 tracer [123I]IBZM.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Ketamine Treatment of Youth Suicide Attempters for Fast Reduction of Severe Suicide Risk and Facilitation of Long-term Collaborative Clinical Engagement: A Randomized Placebo Controlled Trial
Ketamine Treatment of Youth Suicide Attempters for Fast Reduction of Severe Suicide Risk and Facilitation of Long-term Collaborative Clinical Engagement: A Randomized Placebo Controlled Trial
Ketamine Treatment of Youth Suicide Attempters for Fast Reduction of Severe Suicide Risk and Facilitation of Long-term Collaborative Clinical Engagement: A Randomized Placebo Controlled Trial
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder