GASTROINTESTINAL LYMPHATIC TISSUE SAMPLING TO DETERMINE ACTIVE HIV1 REPLICATE

有令人信服的理论理由来研究接受抗逆转录病毒药物治疗的艾滋病毒感染者肠道相关淋巴组织(GALT)中的病毒和免疫反应。GALT含有体内约50%的淋巴组织，在许多患者中用作初始HIV接种的部位，GALT中的绝大多数淋巴细胞表达记忆表型标记(如CD45RO)并被长期激活，从而增强这些细胞的HIV感染。面对强大的联合抗逆转录病毒药物，我们将评估感染艾滋病毒的腐烂细胞以及在这个身体隔室的FDC网络中捕获的艾滋病毒。我们还将评估CD4+淋巴细胞在GALT中的再充盈率，这可能发生在它们在外周血中重新充填之前。

There are compelling theoretical reasons to study the viral and immune response in the gut-associated lymphoid tissue (GALT) in HIV-infected individuals who have been treated with antiretroviral medication. The GALT contains approximately 50% of the lymphoid mass in the body, it serves as the site of initial HIV inoculation in many patients, and the vast majority of the lymphocytes in the GALT express memory phenotypic markers (e.g., CD45RO) and are chronically activated, which enhances HIV infection of these cells. We will evaluate the decay cells infected with HIV as well as trapped HIV in the FDC-network in this body compartment in the face of potent combination antiretroviral medication. We will also evaluate the repopulation rate of CD4+ lymphocytes in the GALT that may occur prior to their repopulation in the peripheral blood.