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EFFECTS OF ACIDOSIS ON EXERCISE INDUCED MUSCLE PROTEIN SYNTHESIS

EFFECTS OF ACIDOSIS ON EXERCISE INDUCED MUSCLE PROTEIN SYNTHESIS
酸中毒对运动引起的肌肉蛋白质合成的影响
批准号：
6264520
负责人：
KIRSTEN L. JOHANSEN
金额：
$0.06万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264520
关键词：
acidosis ammonium chloride biopsy clinical research clinical trial phase I exercise human subject muscle metabolism muscle proteins protein biosynthesis

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中文摘要
翻译
本研究将研究实验诱导的代谢性酸中毒对肌肉活检样本中蛋白质合成的影响，这些样本是在一次阻力运动前后获得的。每个科目将被评估两次。在一次入院时，他们将接受NH4CL诱导酸中毒，另一次接受安慰剂。在酸中毒和正常情况下，将比较运动和未运动肢体肌肉合成率的差异，以检验酸中毒会限制运动合成代谢反应的假设。
英文摘要
This study will examine the effects of experimentally-induced metabolic acidosis on the synthesis of protein in muscle biopsy samples obtained before and after a bout of resistance exercise. Each subject will be evaluated twice. On one admission they will received NH4CL to induce acidosis, on the other placebo. The difference in muscle synthesis rates in the exercised and non-exercised limb will be compared under acidotic and normal conditions to test the hypothesis that acidosis will limit the anabolic response to exercise.
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