Prevalence and Impact of Frailty among Dialysis Patients

透析患者虚弱的患病率和影响

• 批准号: 10180945
• 负责人: KIRSTEN L. JOHANSEN
• 金额: $ 14.9万
• 依托单位: HENNEPIN HEALTHCARE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-18 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10180945
• 关键词: Adverse event; Age; Award; Biological Markers; Body Weight decreased; C-reactive protein; Caring; Cessation of life; Chronic Disease; Chronic Kidney Failure; Clinical; Communities; Data; Development; Dialysis patients; Dialysis procedure; Elderly; End stage renal failure; Environment; Evaluation; Evolution; Fluid overload; Fracture; Functional disorder; Funding; Hemodialysis; Hormones; Hospitalization; Impairment; Individual; Inflammation; Inflammatory; Interleukin-6; Intervention; Kidney Transplantation; Lead; Maintenance; Measures; Mentors; Nephrology; Outcome; Patient Self-Report; Patients; Phenotype; Physical Function; Physical Performance; Physical activity; Physical assessment; Physiological; Polypharmacy; Population; Prevalence; Prevention; Proxy; Recovery; Reporting; Research; Research Personnel; Research Support; Resolution; Risk; Risk Factors; Sampling; Serum; Sleep; Stress; Sum; Syndrome; System; TNF gene; Testing; Testosterone; Time; Training; Transplantation; Treatment outcome; Tumor Necrosis Factor Receptor; United States National Institutes of Health; Veterans; Work; adipokines; adverse outcome; career; clinical care; cohort; comorbidity; demographics; disability; exhaustion; falls; frailty; functional status; high risk; improved; improved functioning; indexing; inflammatory marker; insight; modifiable risk; muscle metabolism; next generation; outcome prediction; patient oriented research; physical inactivity; post-transplant; premature; prevent; prognostic; prognostic value; programs; remediation; risk prediction model; sex

PROJECT SUMMARY/ABSTRACT I am applying to renew my Mid-career Investigator Award in Patient Oriented Research (K24) in order to support my research and mentoring efforts. I am fully committed to patient oriented research and to training the next generation of researchers in nephrology research. I have developed a research program studying physical functioning in patients on dialysis, characterizing their limitations, studying the pathophysiology, and evaluating interventions to improve functioning. While my previous and currently funded work aims to assess frailty and its evolution among patients on dialysis, I am convinced that physical function and frailty could add important information to inform clinical care at other points along the spectrum of CKD. In particular, I plan to expand my focus to the transitions of care from non-dialysis requiring CKD to ESRD and from dialysis to transplantation. Aims are to examine associations of functional status during CKD with outcomes during ESRD in a national cohort of veterans and to measure physical performance in a cohort of kidney transplant candidates to determine the extent to which post-transplant outcomes are related to physical performance and frailty during pre-transplant evaluation. I have a strong track record of mentoring, and I work within a rich, supportive, and collegial environment at UCSF and in the Division of Nephrology. Continued K24 funding will permit me to continue to focus more of my time on research and mentoring and less on clinical and administrative work.

项目概要/摘要 我正在申请续签我的以患者为导向的研究 (K24) 职业生涯中期研究员奖，以便 支持我的研究和指导工作。我完全致力于以患者为导向的研究并培训 肾脏病学研究的下一代研究人员。我制定了一项研究物理的研究计划 透析患者的功能，描述其局限性，研究病理生理学，并评估 改善功能的干预措施。虽然我之前和目前资助的工作旨在评估虚弱及其 透析患者的进化，我相信身体功能和虚弱可能会增加重要的 为 CKD 范围内其他方面的临床护理提供信息。特别是，我计划扩大我的 重点关注从需要 CKD 的非透析到 ESRD 以及从透析到移植的护理转变。 目的是在全国范围内检查 CKD 期间的功能状态与 ESRD 期间的结果之间的关联 退伍军人队列并测量肾移植候选人队列的身体表现 确定移植后结果与身体表现和虚弱程度相关的程度 移植前评估。我在指导方面有着良好的记录，并且在一个丰富、支持和支持的环境中工作。 加州大学旧金山分校和肾脏科的学院环境。持续的 K24 资助将使我能够 继续将更多时间集中在研究和指导上，而不是临床和行政工作上。

项目成果

Determinants of hemodialysis-induced segmental wall motion abnormalities.

• DOI: 10.1111/hdi.12111
• 发表时间: 2014-04
• 期刊: Hemodialysis international. International Symposium on Home Hemodialysis
• 作者: Dubin RF;Beatty AL;Teerlink JR;Schiller NB;Bolger AF;Alokozai D;Peralta CA;Johansen KL
• 通讯作者: Johansen KL

Use of Antihypertensive Agents and Association With Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers.

• DOI: 10.1161/jaha.118.009992
• 发表时间: 2018-10-02
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Ku E;McCulloch CE;Vittinghoff E;Lin F;Johansen KL
• 通讯作者: Johansen KL

Exercise in individuals with CKD.

• DOI: 10.1053/j.ajkd.2011.10.008
• 发表时间: 2012-01
• 期刊: American journal of kidney diseases : the official journal of the National Kidney Foundation
• 作者: Johansen KL;Painter P
• 通讯作者: Painter P

Iron and infection in hemodialysis patients.

血液透析患者的铁和感染。

• DOI: 10.1111/sdi.12168
• 发表时间: 2014-01
• 期刊: Seminars in dialysis
• 影响因子: 1.6
• 作者: Ishida JH;Johansen KL
• 通讯作者: Johansen KL

Correlates and Consequences of High Serum Irisin Concentration in Patients on Hemodialysis: A Longitudinal Analysis.

• DOI: 10.1053/j.jrn.2020.05.005
• 发表时间: 2021-07
• 期刊: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
• 作者: Chiang JM;Delgado C;Kaysen GA;Segal MR;Chertow GM;Johansen KL
• 通讯作者: Johansen KL