Prevalence and Impact of Frailty among Dialysis Patients

透析患者虚弱的患病率和影响

基本信息

批准号：
9926254
负责人：
KIRSTEN L. JOHANSEN
金额：
$ 14.88万
依托单位：
HENNEPIN HEALTHCARE RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-12-18 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9926254
关键词：
Adverse event Age Award Biological Markers Body Weight decreased C-reactive protein Caring Cessation of life Chronic Disease Chronic Kidney Failure Clinical Communities Data Development Dialysis patients Dialysis procedure Elderly End stage renal failure Environment Evaluation Evolution Fluid overload Fracture Functional disorder Funding Hemodialysis Hormones Hospitalization Impairment Individual Inflammation Inflammatory Interleukin-6 Intervention Kidney Transplantation Lead Maintenance Measures Mentors Nephrology Outcome Patient Self-Report Patients Phenotype Physical Function Physical Performance Physical activity Physical assessment Physiological Polypharmacy Population Prevalence Prevention Proxy Recovery Reporting Research Research Personnel Research Support Resolution Risk Risk Factors Sampling Serum Sleep Stress Sum Syndrome System TNF gene Testing Testosterone Time Training Transplantation Treatment outcome Tumor Necrosis Factor Receptor United States National Institutes of Health Veterans Work adipokines adverse outcome career clinical care cohort comorbidity demographics disability exhaustion falls frailty functional status high risk improved improved functioning indexing inflammatory marker insight modifiable risk muscle metabolism next generation outcome prediction patient oriented research physical inactivity post-transplant premature prevent prognostic prognostic value programs remediation risk prediction model sex

项目摘要

PROJECT SUMMARY/ABSTRACT I am applying to renew my Mid-career Investigator Award in Patient Oriented Research (K24) in order to support my research and mentoring efforts. I am fully committed to patient oriented research and to training the next generation of researchers in nephrology research. I have developed a research program studying physical functioning in patients on dialysis, characterizing their limitations, studying the pathophysiology, and evaluating interventions to improve functioning. While my previous and currently funded work aims to assess frailty and its evolution among patients on dialysis, I am convinced that physical function and frailty could add important information to inform clinical care at other points along the spectrum of CKD. In particular, I plan to expand my focus to the transitions of care from non-dialysis requiring CKD to ESRD and from dialysis to transplantation. Aims are to examine associations of functional status during CKD with outcomes during ESRD in a national cohort of veterans and to measure physical performance in a cohort of kidney transplant candidates to determine the extent to which post-transplant outcomes are related to physical performance and frailty during pre-transplant evaluation. I have a strong track record of mentoring, and I work within a rich, supportive, and collegial environment at UCSF and in the Division of Nephrology. Continued K24 funding will permit me to continue to focus more of my time on research and mentoring and less on clinical and administrative work.

项目摘要/摘要我正在申请以患者为导向研究（K24）的中级研究员奖，以便为了支持我的研究和指导工作。我完全致力于以患者为导向的研究，并培训下一代肾脏病研究的研究人员。我已经开发了一个研究身体的研究计划在透析患者中发挥作用，表征其局限性，研究病理生理学并评估改善功能的干预措施。尽管我以前的和目前资助的工作旨在评估脆弱的透析患者的进化，我坚信身体机能和脆弱可能会增加重要信息以在CKD范围的其他位置为临床护理提供信息。特别是，我计划扩大我的专注于从需要CKD到ESRD的非透析以及从透析到移植的护理过渡。目的是检查CKD期间功能状态的关联与ESRD期间的结果退伍军人队列并测量一系列肾脏移植候选者的身体表现确定移植后结局在多大程度上与身体表现和脆弱有关移植前评估。我的指导有很强的记录，我在一个丰富，支持的和 UCSF和肾脏科的大学环境。继续K24的资金将使我能够继续将更多的时间集中在研究和指导上，而更少的时间将其放在临床和行政工作上。