OVARIAN CANCER GENE THERAPY WITH BRCA1

我们正在研究阻止卵巢癌生长的可能性 通过增加主要基因的表达， 卵巢癌BRCA1我们已经证明BRCA1基因转移 进入癌细胞抑制其生长并减少肿瘤的发生。 人癌细胞在裸鼠中的生长。因为BRCA1似乎是一种分泌的 生长抑制剂，它是基因治疗研究的理想基因， 仅转导中等百分比的肿瘤细胞， 产生足够的生长抑制剂来抑制所有的肿瘤细胞。的 本研究的目的是使用一种失活的小鼠病毒， BRCA1基因导入卵巢癌细胞，以确定这是否会抑制 癌细胞在患者体内的生长和扩散。我们 几乎完成了这项研究的招募阶段，因此每年 追踪检查外周血中的逆转录病毒载体， 目前还有其他的测试需要我们关注。

We are studying the possibility of arresting the growth of ovarian cancer by increasing expression of the major gene responsible for hereditary ovarian cancer, BRCA1. We have demonstrated that gene transfer of BRCA1 into cancer cells inhibits their growth and reduces tumorigenesis of human cancer cells in nude mice. Because BRCA1 appears be a secreted growth inhibitor, it is an ideal gene for gene therapy studies because transduction of only a moderate percentage of tumor cells apparently produces enough growth inhibitor to inhibit all tumor cells. The purpose of this study is to use a disabled mouse virus to introduce the BRCA1 gene into ovarian cancer cells to determine if this will inhibit the growth and spread of the cancer cells within the patient. We are almost finished with the recruitment phase of this study, thus the yearly follow up examines for retroviral vector in the peripheral blood and other tests will require our attentions currently.