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NEURAL SUBSTRATES OF COGNITION IN AGING AND ALZHEIMER'S DISEASE

NEURAL SUBSTRATES OF COGNITION IN AGING AND ALZHEIMER'S DISEASE
衰老和阿尔茨海默病中认知的神经基础
批准号：
6115557
负责人：
SUZANNE H CORKIN
金额：
$4.04万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115557
关键词：
Alzheimer's disease aging biomarker clinical research cognition functional magnetic resonance imaging human old age (65+) human subject long term memory longitudinal human study neurophysiology psychomotor function visual perception young adult human (21-34)

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中文摘要
翻译
使用新的高速功能磁共振成像方法(a)获得衰老和阿尔茨海默病特定认知变化的神经基质线索，(b)记录这些变化的个体差异，以及(c)识别可能预示早期阿尔茨海默病的神经生理标志物。为了实现这些目标，我们将在5年的时间里每年对AD患者、老年对照组和年轻对照组进行60次功能磁共振成像研究。我们将研究fMRI信号与三个易受衰老和AD影响的认知领域的行为之间的相关性：长期外显记忆、视觉感知和运动控制。
英文摘要
To use novel high-speed fMRI methods to (a) obtain clues about the neural substrates of specific cognitive changes in aging and AD, (b) document individual differences in those changes, and (c) identify neurophysiological markers that may signal very early AD. In order to achieve these goals, we shall perform 60 fMRI studies per year over a 5-year period in subjects with AD, older control subjects, and young control subjects. We shall examine correlations between fMRI signal and behavior in three cognitive domains that are vulnerable to the effects of aging and AD: long-term explicit memory, visual perception, and motor control.
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