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TAMOXIFEN AND 9 CIS RETINOIC ACID IN ADVANCED BREAST CANCER

TAMOXIFEN AND 9 CIS RETINOIC ACID IN ADVANCED BREAST CANCER
他莫昔芬和 9 顺式维甲酸治疗晚期乳腺癌
批准号：
6115725
负责人：
CAROLYN WASSERHEIT
金额：
$2.1万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115725
关键词：
breast neoplasms clinical research clinical trial phase I combination chemotherapy drug screening /evaluation female human subject human therapy evaluation neoplasm /cancer chemotherapy pharmacokinetics retinoate tamoxifen

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中文摘要
翻译
这项I期试验将试图确定标准剂量他莫昔芬与9-顺式维甲酸联合的最大耐受量和药代动力学。将确定剂量限制毒性、应答率、反应持续时间和生存时间。维甲酸受体、维甲酸X受体和维甲酸孤儿受体在患者原发和转移肿瘤组织中的不同亚型的水平将被描述。核心实验室已经生产、提纯和滴定了一种表达维甲酸受体的腺病毒载体，用于与乳腺癌相关的临床前研究。
英文摘要
This Phase I trial will attempt to determine the maximally tolerated dose and pharmacokinetics of a combination of standard dose tamoxifen with 9-cis retinoic acid. Dose-limiting toxicity, response rate, duration of response, and survival will be determined. Levels of the various subtypes of retinoic acid receptors, retinoid X receptor, and retinoid orphan receptor mRNA and protein in tissue derived from the patient's primary and metastatic tumors will be characterized. The core lab has produced, purified, and titered an adenovirus vector expressing the retinoic acid receptor for preclinical studies relevant to breast cancer.
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DOXIL & TAXOTERE IN PATIENTS W/ ADVANCED MALIGNANCIES
TAMOXIFEN AND 9 CIS RETINOIC ACID IN ADVANCED BREAST CANCER
DOXIL & TAXOTERE IN PATIENTS W/ ADVANCED MALIGNANCIES
DOXORUBICIN AND EDATREXATE IN THE TREATMENT OF SOLID TUMORS
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