CORE--COLORECTAL AND PANCREATIC CANCER PATIENT REGISTRY

1973年，一项遗传性糖尿病患者的登记和临床研究 息肉和结直肠癌综合征是在约翰斯医院开始的 霍普金斯医院。1984年，成立了肠道肿瘤工作组，以 研究结直肠肿瘤生物学并扩大登记范围 功能。书记官处保存在计算机化的dBASE III数据库中 包括：1)716份家族史和食物频率调查问卷 接受结直肠肿瘤评估的患者，2)2120个家庭 根据他们的家族历史登记在登记处，包括 遗传性结直肠癌综合征家族、家族聚集性 结直肠癌和早发性结直肠癌的风险。其核心是 孢子现在已经扩大到包括胰腺癌患者。 目前，结直肠癌和胰腺癌的核心收集家庭 来自受影响和高危人群的病史、饮食数据 家庭和环境因素在老年精神疾病中的作用研究 结直肠癌和胰腺癌的分子遗传学改变。

In 1973, a registry and clinical study of patients with hereditary polyposis and colorectal cancer syndromes was initiated at The Johns Hopkins Hospital. In 1984, the Bowel Tumor Working Group was formed to study the biology of colorectal tumors and to expand the Registry functions. The Registry is maintained in a computerized Dbase III database and includes: 1) family histories and food frequency questionnaires of 716 patients evaluated for colorectal neoplasia and, 2) 2120 families who have been enrolled in the Registry based on their family history, including families with hereditary colorectal cancer syndromes, familial aggregation of colorectal cancer and early onset of colorectal cancer. The Core for the SPORE has now been expanded to included pancreatic cancer patients. Presently, the CORE for Colorectal and Pancreatic Cancer collects family history, dietary data from affected and at-risk individuals to support investigations of the role of familial and environmental factors in the molecular genetic alterations in both colorectal and pancreatic carcinoma.