Dissecting commitment to apoptosis
Dissecting commitment to apoptosis
批准号:
nhmrc : 575559
负责人:
Dr Jacqueline Gulbis
金额:
$38.84万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
在癌细胞中,正常的细胞死亡过程(称为凋亡)是有缺陷的,这有助于异常细胞不受控制地生长和繁殖。Bak蛋白是凋亡调节因子Bcl-2家族的一员,在介导细胞死亡中起关键作用。通过定义bac介导的细胞凋亡的每个步骤,我们的目标是更好地了解癌细胞是如何积累的,以及靶向Bcl-2家族如何导致有效的抗癌治疗。
英文摘要
In cancer cells the normal process of cell death (called apoptosis) is defective, helping abnormal cells to grow and multiply unchecked. The Bak protein is a member of the Bcl-2 family of apoptosis regulators, and plays a pivotal role in mediating cell death. By defining each step in Bak-mediated apoptosis, we aim to better understand how cancer cells accumulate, and how targeting the Bcl-2 family may lead to effective anti-cancer therapeutics.
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