BIOBEHAVIORAL MECHANISMS OF BLOOD PRESSURE REGULATION

目的：探讨生物行为因素在脑梗死发病中的作用 高血压和向心性左心室肥厚 研究了一份血压正常和临界血压的200份血压样本 高血压男性和女性，年龄在25 - 39岁之间，150例术前和术后 年龄为48 - 55岁的绝经期妇女将接受测试。 向心性左 心室肥大和向心性重构通过以下方法评估： 超声心动图测量左心室质量和相对室壁 厚 实验室程序用于：（i）评估血液动力学和 在暴露于不同的物理电池的神经体液反应 和心理压力，和;（ii）评估和肾上腺素能受体 反应性、压力感受器反射增益和血管结构。 以来 血压在一个典型的工作日是一个既定的预测 左心室肥大，也将进行评估。 将测试一种新的生物行为模型， 发病机制中的行为诱发升压反应模式 向心性左心室肥厚 该模型的一个预测是， 在治疗过程中， 压力（非裔美国人的特征）将有利于发展 向心性肥大 因此，全身血管阻力反应， 在实验室评估，假设独立预测 左心室质量和相对壁厚，即使在控制 确定的风险因素，包括工作日血压。 将检查交感神经系统功能，以测试假设 种族、性别和更年期对妇女的影响 血压调节的血流动力学模式。

Purpose: The contributions of biobehavioral factors in the pathogenesis of hypertension and concentric left ventricular hypertrophy are being investigated. A biracial sample totaling 200 normotensive and borderline hypertensive men and women, aged 25-39 years, and 150 pre- and post- menopausal women, aged 48-55 years, are to be tested. Concentric left ventricular hypertrophy and concentric remodeling are assessed by echocardiographic measures of left ventricular mass and relative wall thickness. Laboratory procedures are used to: (i) assess hemodynamic and neurohumoral responses during exposure to a diverse battery of physical and psychological stressors, and; (ii) evaluate and adrenergic receptor responsiveness, baroreceptor reflex gain and vascular structure. Since blood pressure during a typical workday is an established predictor of left ventricular hypertrophy, it will also be assessed. A new biobehavioral model will be tested that implicates the hemodynamic pattern of behaviorally-evoked pressor responses in the pathogenesis of concentric left ventricular hypertrophy. One prediction of this model is that a predisposition to exhibit increased vascular resistance during stress (characteristic of African American men) will favor the development of concentric hypertrophy. Thus, systemic vascular resistance responses, evaluated in the laboratory, are hypothesized to independently predict left ventricular mass and relative wall thickness, even after controlling for established risk factors, including workday blood pressure. Sympathetic nervous system function will be examined to test hypothesized mechanisms responsible for ethnic, gender and menopause effects on the hemodynamic patterns of blood pressure regulation.