Dissecting the role of the adipokine leptin in control of the inflammatory response to Helicobacter pylori

幽门螺杆菌是一种引起慢性胃炎(胃炎)的细菌，可能导致癌症。大约20%的澳大利亚人被感染。作为寻找人类疫苗的一部分，我们正试图了解对这种细菌的免疫反应。这项研究将调查一项新的观察，即脂肪细胞产生的脂肪因子-小蛋白可以调节胃内免疫细胞的活动，从而决定疫苗接种是否有效。

Helicobacter pylori is a bacterium that causes chronic gastric inflammation (gastritis), which may lead to cancer. Approximately 20% of Australians are infected. As part of the search for a human vaccine, we are attempting to understand the immune response against this bacterium. This study will investigate a novel observation that adipokines-small proteins produced by fat cells can regulate the actions of immune cells in the stomach and in this way determine whether vaccination works.