Dissecting the role of insulin-regulated phosphorylation of Rab guanine nucleotide exchange factors in GLUT4 trafficking
Dissecting the role of insulin-regulated phosphorylation of Rab guanine nucleotide exchange factors in GLUT4 trafficking
批准号:
nhmrc : 1047067
负责人:
Dr Jacqueline Stoeckli
金额:
$41.91万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31
中文摘要
糖尿病和肥胖症在发达国家很流行。胰岛素作用受损是主要原因。一个关键因素是肌肉和脂肪对葡萄糖的吸收减少,导致胰腺过度分泌胰岛素。我们最近发现了三种新的分子,我们相信它们掌握着胰岛素如何调节餐后血液中葡萄糖的清除的秘密。本文主要研究这三种分子及其调控。
英文摘要
Diabetes and obesity are epidemic in the developed world. Impaired insulin action is a major cause. A key contributor is reduced glucose uptake into muscle and fat driving the pancreas to overproduce insulin. We have recently discovered three new molecules that we believe hold the secret to how insulin regulates the removal of the glucose from the blood stream after a meal. This proposal focuses on these three molecules and their regulation.
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会议论文
Dissecting Rapamycin sensitive and insensitive effects of mTOR
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批准号:nhmrc : GNT1120201
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项目类别:Project Grants
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资助金额:$118.32万
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财政年份:2017
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负责人:Dr Jacqueline Stoeckli
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依托单位:
Dissecting Rapamycin sensitive and insensitive effects of mTOR
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项目类别:Project Grants
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负责人:Dr Jacqueline Stoeckli
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依托单位:
Functional analysis of the Rab GAP AS160
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批准号:nhmrc : 1068469
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项目类别:Project Grants
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资助金额:$32.35万
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财政年份:2014
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负责人:Dr Jacqueline Stoeckli
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依托单位:
The role of Rab GTPases and Rab GTPase activating proteins in Insulin Action
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批准号:nhmrc : 535923
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项目类别:NHMRC Project Grants
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资助金额:$50.79万
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财政年份:2009
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负责人:Dr Jacqueline Stoeckli
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依托单位:
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:刘耀宝
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项目类别:面上项目
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资助金额:49.00万元
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负责人:赵培泉
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依托单位: